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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307083 Species: Rattus norvegicus RGD Object: Gene Symbol: Tp73 Name: tumor protein p73

Acc ID: CHEBI:4911 Term: etoposide Definition: A beta-D-glucoside that has formula C29H32O13. CasRN: 33419-42-0 Chemical ID: MESH:D005047

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1316062	6480464	CTD	Etoposide results in increased expression of TP73 mRNA	PMID:17716971
increases expression	ISO	RGD:1316062	6480464	CTD	Etoposide results in increased expression of TP73 protein	PMID:21801448 PMID:17716971
multiple interactions	ISO	RGD:1316062	6480464	CTD	[[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol TP73 protein affects the reaction [Etoposide results in increased expression of VDR mRNA]	PMID:17716971
multiple interactions	ISO	RGD:1316062	6480464	CTD	TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP3 protein] TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP7 protein] TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein] TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein]	PMID:21801448
increases expression	ISO	RGD:1316062	6480464	CTD	Etoposide results in increased expression of TP73 protein	PMID:17716971 PMID:21801448