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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307083 Species: Rattus norvegicus RGD Object: Gene Symbol: Tp73 Name: tumor protein p73

Acc ID: CHEBI:27899 Term: cisplatin Definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. CasRN: 15663-27-1 Chemical ID: MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1316062	6480464	CTD	[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein TP73 protein results in increased susceptibility to [Sirolimus co-treated with Cisplatin]	PMID:20686837
increases response to substance	ISO	RGD:1316062	6480464	CTD	TP73 protein modified form results in increased susceptibility to Cisplatin	PMID:21516125
decreases expression	ISO	RGD:1316063	6480464	CTD	Cisplatin results in decreased expression of TRP73 alternative form	PMID:22002055
decreases response to substance	ISO	RGD:1316063	6480464	CTD	TRP73 alternative form results in decreased susceptibility to Cisplatin	PMID:22002055
increases expression	ISO	RGD:1316063	6480464	CTD	Cisplatin results in increased expression of TRP73	PMID:22002055
multiple interactions	ISO	RGD:1316062	6480464	CTD	calpeptin inhibits the reaction [Cisplatin results in decreased expression of TP73 protein modified form] TP73 protein modified form promotes the reaction [Cisplatin results in increased expression of BBC3 protein] TP73 protein modified form promotes the reaction [Cisplatin results in increased expression of PMAIP1 protein]	PMID:21516125
affects localization	ISO	RGD:1316062	6480464	CTD	Cisplatin affects the localization of TP73 protein modified form	PMID:21516125
multiple interactions	ISO	RGD:1316062	6480464	CTD	[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 mRNA [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX mRNA [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX protein [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS mRNA [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS protein [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 mRNA [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B mRNA [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein [[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein [[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein [[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein [[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein [[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein] [YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein [YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein [YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein [YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein [YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein	PMID:21214929
multiple interactions	ISO	RGD:1316062	6480464	CTD	Cisplatin promotes the reaction [[TP73 protein binds to IL4R intron] which results in increased expression of IL4R mRNA]	PMID:14678968
decreases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in decreased expression of TP73 mRNA	PMID:21737676
multiple interactions	ISO	RGD:1316062	6480464	CTD	Cisplatin promotes the reaction [[TP73 protein binds to GRAMD4 promoter] which results in increased expression of GRAMD4 mRNA] TP73 protein promotes the reaction [Cisplatin results in increased expression of GRAMD4 mRNA]	PMID:21127500
decreases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in decreased expression of TP73 protein modified form	PMID:21516125
increases activity	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased activity of TP73 protein	PMID:14678968
increases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased expression of TP73 protein	PMID:21274007 PMID:17076661 PMID:21214929 PMID:20655883
multiple interactions	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased localization of [PLK1 protein co-treated with TP73 protein] PLK1 protein inhibits the reaction [Cisplatin results in increased expression of TP73 protein]	PMID:20655883
multiple interactions	ISO	RGD:1316062	6480464	CTD	RELA protein mutant form inhibits the reaction [Cisplatin results in decreased expression of TP73 mRNA] TP73 mutant form inhibits the reaction [RELA promotes the reaction [Cisplatin results in increased expression of PMAIP1 mRNA]]	PMID:21737676
increases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased expression of TP73 protein	PMID:21214929 PMID:20655883 PMID:17076661 PMID:21274007
increases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased expression of TP73 protein	PMID:21214929 PMID:17076661 PMID:21274007 PMID:20655883
increases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased expression of TP73 protein	PMID:21274007 PMID:21214929 PMID:20655883 PMID:17076661
increases response to substance	ISO	RGD:1316062	6480464	CTD	TP73 results in increased susceptibility to Cisplatin	PMID:20100536
multiple interactions	ISO	RGD:1316062	6480464	CTD	[Cisplatin co-treated with TP73 protein] results in increased expression of BAX protein [Cisplatin co-treated with TP73 protein] results in increased expression of CDKN1A protein	PMID:20100536
increases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased expression of TP73 protein	PMID:21274007 PMID:20655883 PMID:21214929 PMID:17076661
increases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased expression of TP73 protein	PMID:17076661 PMID:21214929 PMID:20655883 PMID:21274007
increases expression	ISO	RGD:1316062	6480464	CTD	Cisplatin results in increased expression of TP73 protein	PMID:17076661 PMID:20655883 PMID:21214929 PMID:21274007