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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Traf6
Name: TNF receptor associated factor 6
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Traf6increases expressionISOTRAF6 (Homo sapiens)6480464CTDParaquat results in increased expression of TRAF6 proteinPMID:27890776
Traf6increases expressionISOTraf6 (Mus musculus)6480464CTDParaquat results in increased expression of TRAF6 proteinPMID:27890776
Traf6multiple interactionsISOTRAF6 (Homo sapiens)6480464CTDepigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein]PMID:27890776
Traf6multiple interactionsISOTraf6 (Mus musculus)6480464CTD[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA]PMID:23963992 PMID:27890776
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