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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chukmultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Fructose results in increased phosphorylation of CHUK protein]; Quercetin inhibits the reaction [Streptozocin results in increased expression of CHUK protein]PMID:16177186 PMID:24491314
Chukdecreases expressionISOCHUK (Homo sapiens)6480464CTDQuercetin results in decreased expression of CHUK mRNAPMID:21632981 PMID:23727915
Chukdecreases phosphorylationISOCHUK (Homo sapiens)6480464CTDQuercetin results in decreased phosphorylation of CHUK proteinPMID:17184768 PMID:20386985
Chukmultiple interactionsISOCHUK (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of CHUK mRNA; AKT1 protein modified form inhibits the reaction [Quercetin results in decreased phosphorylation of CHUK protein]; Quercetin inhibits the reaction [TNF protein affects the localization of CHUK protein]PMID:20386985 PMID:22452660 PMID:27514524
Chukmultiple interactionsISOChuk (Mus musculus)6480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]PMID:16171798
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