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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mki67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mki67increases expressionEXP 6480464CTDTamoxifen results in increased expression of MKI67 proteinPMID:17219426
Mki67decreases expressionISOMKI67 (Homo sapiens)6480464CTDTamoxifen results in decreased expression of MKI67 proteinPMID:15767642 PMID:16002280 PMID:18855134 PMID:20332317
Mki67decreases expressionISOMki67 (Mus musculus)6480464CTDTamoxifen results in decreased expression of MKI67 proteinPMID:15067354
Mki67increases expressionISOMKI67 (Homo sapiens)6480464CTDTamoxifen results in increased expression of MKI67 proteinPMID:12627041
Mki67multiple interactionsISOMKI67 (Homo sapiens)6480464CTD[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein; [Tamoxifen co-treated with anastrozole] results in decreased expression of MKI67 proteinPMID:15767642 PMID:18855134
Mki67multiple interactionsISOMki67 (Mus musculus)6480464CTDQuercetin promotes the reaction [Tamoxifen results in decreased expression of MKI67 protein]PMID:15067354
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