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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2decreases expressionISOMDM2 (Homo sapiens)6480464CTD[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of MDM2 mRNA; Curcumin results in decreased expression of MDM2 proteinPMID:17332326
Mdm2increases expressionISOMDM2 (Homo sapiens)6480464CTDCurcumin analog results in increased expression of MDM2 mRNAPMID:26409325
Mdm2multiple interactionsISOMDM2 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein]PMID:24831732
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