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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2increases phosphorylationISOMDM2 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of MDM2 proteinPMID:19751709 PMID:20840854
Mdm2multiple interactionsISOMDM2 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; MDM2 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased phosphorylation of FOXO3 protein]PMID:20840854
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