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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2affects expressionISOMDM2 (Homo sapiens)6480464CTDZinc affects the expression of MDM2 proteinPMID:16636310
Mdm2increases ubiquitinationISOMDM2 (Homo sapiens)6480464CTDZinc results in increased ubiquitination of MDM2 proteinPMID:16965791
Mdm2multiple interactionsISOMDM2 (Homo sapiens)6480464CTDZinc binds to and results in increased folding of MDM2 protein; Zinc promotes the reaction [MDM2 protein binds to MDM2 protein]; Zinc promotes the reaction [MDM2 protein binds to MDM4 protein]PMID:16965791
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