Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1305332
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Mdm2
Name:	MDM2 proto-oncogene

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Mdm2	decreases expression	EXP		6480464	CTD	Cisplatin results in decreased expression of MDM2 mRNA; Cisplatin results in decreased expression of MDM2 protein	PMID:35842499
Mdm2	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of MDM2 mRNA	PMID:24880025
Mdm2	multiple interactions	EXP		6480464	CTD	Cisplatin promotes the reaction [NFE2L2 protein results in increased expression of MDM2 mRNA]; NFE2L2 protein inhibits the reaction [Cisplatin results in decreased expression of MDM2 mRNA]; NFE2L2 protein inhibits the reaction [Cisplatin results in decreased expression of MDM2 protein]	PMID:35842499
Mdm2	increases expression	ISO	MDM2 (Homo sapiens)	6480464	CTD	Cisplatin results in increased expression of MDM2 mRNA; Cisplatin results in increased expression of MDM2 protein	PMID:16797627 PMID:24280081 PMID:25450742 PMID:25596134 PMID:33545341
Mdm2	increases expression	ISO	Mdm2 (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of MDM2 mRNA; Cisplatin results in increased expression of MDM2 protein	PMID:21151649 PMID:24280081 PMID:25270620 PMID:35842499
Mdm2	multiple interactions	ISO	MDM2 (Homo sapiens)	6480464	CTD	[Cisplatin co-treated with eprenetapopt co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA; [Cisplatin co-treated with eprenetapopt] results in increased expression of MDM2 mRNA; [TP53 protein binds to MDM2 protein] which results in decreased susceptibility to Cisplatin; Cisplatin promotes the reaction [TP53 protein binds to MDM2 promoter]; Cisplatin promotes the reaction [TP53 protein results in increased expression of MDM2]; Cisplatin results in increased activity of and results in increased expression of MDM2 protein; nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]; TP53 affects the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]	PMID:21509038 PMID:21552291 PMID:21624110 PMID:29690507
Mdm2	multiple interactions	ISO	Mdm2 (Mus musculus)	6480464	CTD	Cisplatin promotes the reaction [TRP53 protein results in increased expression of MDM2]; NFE2L2 protein affects the reaction [Cisplatin results in increased expression of MDM2 mRNA]; NFE2L2 protein affects the reaction [Cisplatin results in increased expression of MDM2 protein]	PMID:21552291 PMID:35842499

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