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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2increases expressionEXP 6480464CTDQuercetin results in increased expression of MDM2 mRNAPMID:31201582
Mdm2multiple interactionsEXP 6480464CTD[Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNAPMID:27525270
Mdm2decreases expressionISOMDM2 (Homo sapiens)6480464CTDQuercetin results in decreased expression of MDM2 proteinPMID:21933852
Mdm2increases expressionISOMDM2 (Homo sapiens)6480464CTDQuercetin results in increased expression of MDM2 mRNAPMID:21632981 PMID:23727915 PMID:24849437
Mdm2multiple interactionsISOMDM2 (Homo sapiens)6480464CTDQuercetin results in decreased phosphorylation of and results in decreased expression of MDM2 proteinPMID:17973296
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