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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303243
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sptb
Name: spectrin, beta, erythrocytic
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sptbaffects methylationISOSPTB (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SPTB promoterPMID:27901495
Sptbdecreases expressionISOSptb (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SPTB mRNAPMID:22228805
Sptbdecreases methylationISOSPTB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of SPTB 3' UTRPMID:27901495
Sptbincreases expressionISOSPTB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of SPTB mRNAPMID:32234424
Sptbincreases methylationISOSPTB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SPTB exonPMID:27901495
Sptbincreases mutagenesisISOSPTB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of SPTB genePMID:25435355
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