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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303075
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90ab1
Name: heat shock protein 90 alpha family class B member 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90ab1affects response to substanceISOHSP90AB1 (Homo sapiens)6480464CTDHSP90AB1 protein affects the susceptibility to Arsenic TrioxidePMID:19371599
Hsp90ab1decreases expressionISOHSP90AB1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of HSP90AB1 proteinPMID:25419056
Hsp90ab1increases expressionISOHSP90AB1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of HSP90AB1 mRNA; Arsenic Trioxide results in increased expression of HSP90AB1 proteinPMID:19364129 PMID:20458559 PMID:22521957
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