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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1302965
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon3
Name: paraoxonase 3
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon3increases hydrolysisISOPON3 (Homo sapiens)6480464CTDPON3 protein results in increased hydrolysis of LovastatinPMID:15772423
Pon3increases metabolic processingISOPon3 (Mus musculus)6480464CTDPON3 protein results in increased metabolism of LovastatinPMID:12615656
Pon3multiple interactionsISOPon3 (Mus musculus)6480464CTD7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]; Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]PMID:12615656
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