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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330 Species: Mus musculus RGD Object: Gene Symbol: Sod2 Name: superoxide dismutase 2, mitochondrial

Acc ID: CHEBI:28939 Term: N-acetyl-L-cysteine Definition: The N-acetylated derivative of natural amino acid L-cysteine. CasRN: 616-91-1 Chemical ID: MESH:D000111

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]	PMID:12031898
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2]	PMID:11264281
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]	PMID:17309078
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein]	PMID:20674559
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of SOD2 mRNA] Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]	PMID:8760145
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein]	PMID:15904944
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine inhibits the reaction [SOD2 protein affects the activity of AR protein] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR1 mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AMACR mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AKR1C3 mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR2 mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of FKBP5 mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of PGR mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of KLK3 mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD17B8 mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD11B2 mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of RXRA mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of TMPRSS2 mRNA] Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of VEGFA mRNA]	PMID:18829485
multiple interactions	EXP		6480464	CTD	Acetylcysteine promotes the reaction [Oxygen results in increased expression of SOD2 mRNA] Acetylcysteine promotes the reaction [Oxygen results in increased expression of SOD2 protein] [Acetylcysteine results in increased expression of SOD2 protein] which results in decreased abundance of Reactive Oxygen Species	PMID:17010595
multiple interactions	ISO	RGD:730872	6480464	CTD	[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of SOD2 mRNA	PMID:22429591
increases expression	EXP		6480464	CTD	Acetylcysteine results in increased expression of SOD2 mRNA Acetylcysteine results in increased expression of SOD2 protein	PMID:17010595
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin] Acetylcysteine affects the reaction [SOD2 protein affects the activity of CASP9 protein] Acetylcysteine affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]	PMID:18594523
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]	PMID:16101137
multiple interactions	ISO	RGD:3732	6480464	CTD	Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of SOD2 protein]	PMID:22714038