RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	11315
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Slc6a3
Name:	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Acc ID:	CHEBI:6809
Term:	methamphetamine
Definition:	An amphetamine that has formula C10H15N.
CasRN:	537-46-2
Chemical ID:	MESH:D008694

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases response to substance	ISO	RGD:733809	6480464	CTD	SLC6A3 3' UTR polymorphism results in increased susceptibility to Methamphetamine	PMID:12931138
multiple interactions	EXP		6480464	CTD	15-deoxyprostaglandin J2 inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] Ibuprofen inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:18946735
multiple interactions	EXP		6480464	CTD	estradiol 3-benzoate inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 mRNA] estradiol 3-benzoate inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:15249736
multiple interactions	EXP		6480464	CTD	7-nitroindazole inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] NOS1 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:20575850
multiple interactions	EXP		6480464	CTD	Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]]	PMID:9765353
multiple interactions	EXP		6480464	CTD	FOS protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:10559418
multiple interactions	EXP		6480464	CTD	IFNG protein inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:18282668
multiple interactions	EXP		6480464	CTD	IL6 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:11093760
multiple interactions	EXP		6480464	CTD	isoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:19834288
multiple interactions	EXP		6480464	CTD	Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein] NOS1 protein affects the reaction [Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]]	PMID:11085313
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 mRNA	PMID:15249736
multiple interactions	EXP		6480464	CTD	Minocycline inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:16839653
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:20575850 PMID:9765353 PMID:10559418 PMID:18946735 PMID:16403784 PMID:12871582 PMID:11093760 PMID:18282668 PMID:19834288 PMID:16839653 PMID:15249736 PMID:18277051
multiple interactions	EXP		6480464	CTD	SLC6A3 protein affects the reaction [Methamphetamine affects the abundance of Dopamine] SLC6A3 protein affects the reaction [Methamphetamine results in increased expression of GFAP mRNA] SLC6A3 protein affects the reaction [Methamphetamine results in increased expression of GFAP protein]	PMID:9634552
decreases response to substance	EXP		6480464	CTD	SLC6A3 gene mutant form results in decreased susceptibility to Methamphetamine	PMID:11222668
affects response to substance	EXP		6480464	CTD	SLC6A3 protein affects the susceptibility to Methamphetamine	PMID:20558209 PMID:12050851
multiple interactions	ISO	RGD:3715	6480464	CTD	Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]	PMID:9132989
multiple interactions	ISO	RGD:3715	6480464	CTD	Methamphetamine inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]	PMID:16897726
decreases activity	ISO	RGD:3715	6480464	CTD	Methamphetamine results in decreased activity of SLC6A3 protein	PMID:19326567 PMID:19046384 PMID:11032899
increases expression	ISO	RGD:3715	6480464	CTD	Methamphetamine results in increased expression of SLC6A3 protein	PMID:15986185
decreases expression	ISO	RGD:3715	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:15900317 PMID:19648469
multiple interactions	ISO	RGD:733809	6480464	CTD	indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]	PMID:17234900
decreases expression	ISO	RGD:733809	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:16518646 PMID:16622715 PMID:17992686 PMID:12944350 PMID:9763484 PMID:15542729
decreases activity	ISO	RGD:733809	6480464	CTD	Methamphetamine results in decreased activity of SLC6A3 protein	PMID:16842981
affects abundance	ISO	RGD:733809	6480464	CTD	SLC6A3 protein affects the abundance of Methamphetamine	PMID:11027249
decreases expression	ISO	RGD:733809	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:12944350 PMID:16518646 PMID:9763484 PMID:17992686 PMID:15542729 PMID:16622715
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:18946735 PMID:20575850 PMID:19834288 PMID:9765353 PMID:11093760 PMID:12871582 PMID:10559418 PMID:18282668 PMID:16839653 PMID:18277051 PMID:15249736 PMID:16403784
decreases expression	ISO	RGD:3715	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:19648469 PMID:15900317
decreases expression	ISO	RGD:733809	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:12944350 PMID:15542729 PMID:16518646 PMID:9763484 PMID:16622715 PMID:17992686
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:12871582 PMID:18282668 PMID:16839653 PMID:18946735 PMID:16403784 PMID:18277051 PMID:11093760 PMID:20575850 PMID:9765353 PMID:10559418 PMID:15249736 PMID:19834288
decreases activity	ISO	RGD:3715	6480464	CTD	Methamphetamine results in decreased activity of SLC6A3 protein	PMID:19046384 PMID:11032899 PMID:19326567
decreases expression	ISO	RGD:733809	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:16518646 PMID:12944350 PMID:15542729 PMID:17992686 PMID:9763484 PMID:16622715
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:9765353 PMID:18282668 PMID:12871582 PMID:15249736 PMID:10559418 PMID:16839653 PMID:18277051 PMID:16403784 PMID:18946735 PMID:20575850 PMID:11093760 PMID:19834288
affects response to substance	EXP		6480464	CTD	SLC6A3 protein affects the susceptibility to Methamphetamine	PMID:12050851 PMID:20558209
decreases expression	ISO	RGD:733809	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:9763484 PMID:15542729 PMID:12944350 PMID:17992686 PMID:16518646 PMID:16622715
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:10559418 PMID:18282668 PMID:12871582 PMID:15249736 PMID:9765353 PMID:19834288 PMID:11093760 PMID:18946735 PMID:20575850 PMID:18277051 PMID:16403784 PMID:16839653
decreases activity	ISO	RGD:3715	6480464	CTD	Methamphetamine results in decreased activity of SLC6A3 protein	PMID:19046384 PMID:19326567 PMID:11032899
decreases expression	ISO	RGD:733809	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:17992686 PMID:9763484 PMID:16518646 PMID:12944350 PMID:16622715 PMID:15542729
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:12871582 PMID:19834288 PMID:18946735 PMID:18282668 PMID:18277051 PMID:10559418 PMID:16403784 PMID:16839653 PMID:20575850 PMID:15249736 PMID:11093760 PMID:9765353
decreases activity	ISO	RGD:3715	6480464	CTD	Methamphetamine results in decreased activity of SLC6A3 protein	PMID:11032899 PMID:19326567 PMID:19046384
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:10559418 PMID:11093760 PMID:12871582 PMID:15249736 PMID:16403784 PMID:16839653 PMID:18277051 PMID:18282668 PMID:18946735 PMID:19834288 PMID:20575850 PMID:9765353
decreases activity	ISO	RGD:3715	6480464	CTD	Methamphetamine results in decreased activity of SLC6A3 protein	PMID:11032899 PMID:19046384 PMID:19326567
decreases expression	ISO	RGD:733809	6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:12944350 PMID:15542729 PMID:16518646 PMID:16622715 PMID:17992686 PMID:9763484
decreases expression	EXP		6480464	CTD	Methamphetamine results in decreased expression of SLC6A3 protein	PMID:10559418 PMID:11093760 PMID:12871582 PMID:15249736 PMID:16403784 PMID:16839653 PMID:18277051 PMID:18282668 PMID:18946735 PMID:19834288 PMID:20575850 PMID:21151937 PMID:9765353
multiple interactions	EXP		6480464	CTD	NR4A2 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]	PMID:21151937

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