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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11184 Species: Mus musculus RGD Object: Gene Symbol: Ptgs1 Name: prostaglandin-endoperoxide synthase 1

Acc ID: CHEBI:160246 Term: aminophenazone Definition: A pyrazol-2-one with analgesic, anti-inflammatory, and antipyretic properties. CasRN: 58-15-1 Chemical ID: MESH:D000632

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:736739	6480464	CTD	Aminopyrine results in decreased activity of PTGS1 protein Aminopyrine analog results in decreased activity of PTGS1 protein	PMID:16141368