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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11068 Species: Mus musculus RGD Object: Gene Symbol: Pdgfb Name: platelet derived growth factor, B polypeptide

Acc ID: CHEBI:9168 Term: sirolimus Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. CasRN: 53123-88-9 Chemical ID: MESH:D020123

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737124	6480464	CTD	Sirolimus inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]	PMID:15919668