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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11068 Species: Mus musculus RGD Object: Gene Symbol: Pdgfb Name: platelet derived growth factor, B polypeptide

Acc ID: CHEBI:45713 Term: trans-resveratrol Definition: A resveratrol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737124	6480464	CTD	resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein] resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	PMID:16343977
increases expression	ISO	RGD:737124	6480464	CTD	resveratrol results in increased expression of PDGFB mRNA	PMID:12002526
decreases activity	ISO	RGD:737124	6480464	CTD	resveratrol results in decreased activity of PDGFB protein	PMID:16343977
multiple interactions	ISO	RGD:737124	6480464	CTD	resveratrol inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased chemical synthesis of Inositol Phosphates] resveratrol results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]	PMID:9581680