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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10812 Species: Mus musculus RGD Object: Gene Symbol: Ins2 Name: insulin II

Acc ID: CHEBI:9123 Term: sertraline Definition: A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder. CasRN: 79617-96-2 Chemical ID: MESH:D020280

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2916	6480464	CTD	Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein] Sertraline inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	PMID:17728140