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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10698
Species: Mus musculus
RGD Object: Gene
Symbol: Gstm2
Name: glutathione S-transferase, mu 2
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm2increases expressionISOGSTM2 (Homo sapiens)6480464CTDDecitabine results in increased expression of GSTM2 mRNAPMID:19900515 PMID:21246532
Gstm2multiple interactionsISOGSTM2 (Homo sapiens)6480464CTD[Decitabine affects the methylation of GSTM2 promoter] which affects the expression of GSTM2 mRNA; [Decitabine affects the methylation of GSTM2 promoter] which affects the expression of GSTM2 protein; Decitabine inhibits the reaction [DNMT3B protein binds to GSTM2 promoter]; Decitabine promotes the reaction [SP1 protein binds to GSTM2 promoter]; trichostatin A promotes the reaction [[Decitabine affects the methylation of GSTM2 promoter] which affects the expression of GSTM2 protein]PMID:18664505 PMID:21246532
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