RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10681
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Gpx1
Name:	glutathione peroxidase 1

Acc ID:	CHEBI:36904
Term:	elemental selenium
Definition:	null
CasRN:	7782-49-2
Chemical ID:	MESH:D012643

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects response to substance	ISO	RGD:737005	6480464	CTD	GPX1 protein polymorphism affects the susceptibility to Selenium	PMID:12810669
affects response to substance	ISO	RGD:737005	6480464	CTD	GPX1 gene polymorphism affects the susceptibility to Selenium	PMID:19415410
affects activity	ISO	RGD:737005	6480464	CTD	Selenium affects the activity of GPX1 protein	PMID:19125369
increases activity	ISO	RGD:737005	6480464	CTD	Selenium results in increased activity of GPX1 protein	PMID:17150329 PMID:15203190 PMID:17512462
decreases expression	ISO	RGD:737005	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:15670848
increases expression	ISO	RGD:737005	6480464	CTD	Selenium results in increased expression of GPX1 mRNA	PMID:10874123 PMID:11776067 PMID:17052796
affects activity	EXP		6480464	CTD	Selenium affects the activity of GPX1 protein	PMID:17513408 PMID:19076066
increases expression	ISO	RGD:737005	6480464	CTD	Selenium results in increased expression of GPX1 protein	PMID:17052796
affects expression	EXP		6480464	CTD	Selenium affects the expression of GPX1 mRNA	PMID:19076066
decreases activity	EXP		6480464	CTD	Selenium deficiency results in decreased activity of GPX1 protein	PMID:15795427
affects expression	EXP		6480464	CTD	Selenium affects the expression of GPX1 protein	PMID:17709542
multiple interactions	EXP		6480464	CTD	Selenium deficiency results in decreased expression of and results in decreased activity of GPX1 protein	PMID:16170372
decreases expression	EXP		6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:15795427 PMID:16170372
affects activity	ISO	RGD:2729	6480464	CTD	Selenium affects the activity of GPX1 protein	PMID:19106321
affects expression	ISO	RGD:2729	6480464	CTD	Selenium affects the expression of GPX1 mRNA	PMID:19106321
multiple interactions	ISO	RGD:2729	6480464	CTD	[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GPX1 mRNA	PMID:11444866
decreases expression	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 protein	PMID:15203381
decreases expression	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:15792362 PMID:10949970 PMID:19234057 PMID:17109141 PMID:11294903 PMID:12667700 PMID:12031252 PMID:11444866 PMID:15670848
multiple interactions	ISO	RGD:2729	6480464	CTD	Selenium inhibits the reaction [Cisplatin results in decreased expression of GPX1 mRNA]	PMID:16837816
increases activity	ISO	RGD:2729	6480464	CTD	Selenium results in increased activity of GPX1 protein	PMID:10949970 PMID:19022953
multiple interactions	ISO	RGD:2729	6480464	CTD	Selenium results in increased expression of and results in decreased degradation of GPX1 mRNA	PMID:11463357
increases expression	ISO	RGD:2729	6480464	CTD	Selenium results in increased expression of GPX1 mRNA	PMID:19022953 PMID:15792362
decreases activity	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased activity of GPX1 protein	PMID:12031252 PMID:19234057 PMID:15203381
increases activity	ISO	RGD:737005	6480464	CTD	Selenium results in increased activity of GPX1 protein	PMID:17512462 PMID:17150329 PMID:15203190
increases expression	ISO	RGD:737005	6480464	CTD	Selenium results in increased expression of GPX1 mRNA	PMID:11776067 PMID:10874123 PMID:17052796
decreases activity	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased activity of GPX1 protein	PMID:15203381 PMID:12031252 PMID:19234057
decreases expression	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:12031252 PMID:15792362 PMID:10949970 PMID:12667700 PMID:15670848 PMID:17109141 PMID:11294903 PMID:11444866 PMID:19234057
increases expression	ISO	RGD:2729	6480464	CTD	Selenium results in increased expression of GPX1 mRNA	PMID:15792362 PMID:19022953
increases activity	ISO	RGD:737005	6480464	CTD	Selenium results in increased activity of GPX1 protein	PMID:15203190 PMID:17150329 PMID:17512462
increases expression	ISO	RGD:737005	6480464	CTD	Selenium results in increased expression of GPX1 mRNA	PMID:17052796 PMID:11776067 PMID:10874123
decreases activity	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased activity of GPX1 protein	PMID:15203381 PMID:19234057 PMID:12031252
decreases expression	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:12031252 PMID:11294903 PMID:10949970 PMID:19234057 PMID:11444866 PMID:12667700 PMID:15670848 PMID:15792362 PMID:17109141
increases activity	ISO	RGD:2729	6480464	CTD	Selenium results in increased activity of GPX1 protein	PMID:19022953 PMID:10949970
increases expression	ISO	RGD:737005	6480464	CTD	Selenium results in increased expression of GPX1 mRNA	PMID:10874123 PMID:17052796 PMID:11776067
affects activity	EXP		6480464	CTD	Selenium affects the activity of GPX1 protein	PMID:19076066 PMID:17513408
decreases expression	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:10949970 PMID:15792362 PMID:19234057 PMID:12667700 PMID:11444866 PMID:17109141 PMID:15670848 PMID:11294903 PMID:12031252
decreases expression	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:17109141 PMID:11444866 PMID:15792362 PMID:12031252 PMID:15670848 PMID:10949970 PMID:19234057 PMID:12667700 PMID:11294903
increases expression	ISO	RGD:737005	6480464	CTD	Selenium results in increased expression of GPX1 mRNA	PMID:11776067 PMID:17052796 PMID:10874123
decreases expression	EXP		6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:16170372 PMID:15795427
decreases activity	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased activity of GPX1 protein	PMID:12031252 PMID:15203381 PMID:19234057
decreases expression	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:15670848 PMID:12667700 PMID:11294903 PMID:12031252 PMID:10949970 PMID:11444866 PMID:15792362 PMID:17109141 PMID:19234057
increases activity	ISO	RGD:737005	6480464	CTD	Selenium results in increased activity of GPX1 protein	PMID:17150329 PMID:17512462 PMID:15203190
decreases expression	ISO	RGD:2729	6480464	CTD	Selenium deficiency results in decreased expression of GPX1 mRNA	PMID:10949970 PMID:11294903 PMID:11444866 PMID:12031252 PMID:12667700 PMID:15670848 PMID:15792362 PMID:17109141 PMID:19234057
multiple interactions	EXP		6480464	CTD	Selenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein] Selenium deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of GPX1 protein]	PMID:21775527

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