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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10681 Species: Mus musculus RGD Object: Gene Symbol: Gpx1 Name: glutathione peroxidase 1

Acc ID: CHEBI:16240 Term: hydrogen peroxide Definition: An inorganic peroxide that has formula H2O2. CasRN: 7722-84-1 Chemical ID: MESH:D006861

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects abundance	ISO	RGD:737005	6480464	CTD	GPX1 protein affects the abundance of Hydrogen Peroxide	PMID:8824885
decreases response to substance	ISO	RGD:737005	6480464	CTD	GPX1 protein results in decreased susceptibility to Hydrogen Peroxide	PMID:14660625 PMID:1939125
increases reduction	ISO	RGD:737005	6480464	CTD	GPX1 protein results in increased reduction of Hydrogen Peroxide	PMID:8428933
multiple interactions	EXP		6480464	CTD	GPX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased acetylation of HIST3H3 protein] GPX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased acetylation of HIST4H4 protein]	PMID:18560803
decreases response to substance	EXP		6480464	CTD	GPX1 protein results in decreased susceptibility to Hydrogen Peroxide	PMID:16721761
multiple interactions	ISO	RGD:2729	6480464	CTD	[Iron co-treated with Hydrogen Peroxide] results in decreased expression of and results in decreased activity of GPX1 protein	PMID:17280487
increases metabolic processing	EXP		6480464	CTD	GPX1 protein results in increased metabolism of Hydrogen Peroxide	PMID:9126277
decreases response to substance	ISO	RGD:737005	6480464	CTD	GPX1 protein results in decreased susceptibility to Hydrogen Peroxide	PMID:1939125 PMID:14660625
affects response to substance	ISO	RGD:737005	6480464	CTD	GPX1 gene polymorphism affects the susceptibility to Hydrogen Peroxide	PMID:20444272
multiple interactions	ISO	RGD:737005	6480464	CTD	[GPX1 gene polymorphism co-treated with ACE gene polymorphism] affects the susceptibility to Hydrogen Peroxide	PMID:20444272
increases expression	ISO	RGD:2729	6480464	CTD	Hydrogen Peroxide results in increased expression of GPX1 mRNA	PMID:19720132