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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652 Species: Mus musculus RGD Object: Gene Symbol: Gclc Name: glutamate-cysteine ligase, catalytic subunit

Acc ID: CHEBI:17515 Term: L-gamma-glutamyl-L-cysteine Definition: A molecular entity formed when L-cysteine amino group binds to the gamma-carbonyl of L-glutamic acid. CasRN: 636-58-8 Chemical ID: MESH:C017341

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:619868	6480464	CTD	Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] Excitatory Amino Acid Agents promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]	PMID:15115889
increases chemical synthesis	ISO	RGD:619868	6480464	CTD	GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine	PMID:15115889