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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:77006
Term: 17beta-estradiol 3-benzoate
Definition: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.
Chemical ID: MESH:C074283
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingEXP 6480464CTDestradiol 3-benzoate binds to ESR1 proteinPMID:11162928
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDestradiol 3-benzoate binds to ESR1 proteinPMID:11162928
Esr1affects expressionISOEsr1 (Rattus norvegicus)6480464CTDestradiol 3-benzoate affects the expression of ESR1 mRNAPMID:15925091 PMID:19350480
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDestradiol 3-benzoate results in decreased expression of ESR1; estradiol 3-benzoate results in decreased expression of ESR1 proteinPMID:15375486 PMID:15778002
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDestradiol 3-benzoate results in increased expression of ESR1 mRNA; estradiol 3-benzoate results in increased expression of ESR1 proteinPMID:15716488 PMID:22016562 PMID:27830003 PMID:32967526
Esr1increases methylationISOEsr1 (Rattus norvegicus)6480464CTDestradiol 3-benzoate results in increased methylation of ESR1 exon; estradiol 3-benzoate results in increased methylation of ESR1 intronPMID:22016562
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDmethyl palmitate inhibits the reaction [estradiol 3-benzoate results in increased expression of ESR1 protein]PMID:32967526
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