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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:76989
Term: phytoestrogen
Definition: Any compound produced by a plant that happens to have estrogenic activity.
Chemical ID: MESH:D048789
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDPhytoestrogens results in decreased expression of ESR1 mRNAPMID:16731787
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDPhytoestrogens results in decreased expression of ESR1 mRNA; Phytoestrogens results in decreased expression of ESR1 proteinPMID:16033089
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDPhytoestrogens results in increased expression of ESR1 mRNAPMID:16731787
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDPhytoestrogens binds to and results in increased activity of ESR1 proteinPMID:16076101
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