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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:3752
Term: clomiphene
Definition: A tertiary amine that has formula C26H28ClNO.
Chemical ID: MESH:D002996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDClomiphene binds to ESR1 proteinPMID:15521089 PMID:19233257
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDClomiphene binds to and results in decreased activity of ESR1 protein; Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Clomiphene promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]PMID:19233257 PMID:25012808 PMID:25752796 PMID:26865669 PMID:33049310 PMID:9048584
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