GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | decreases expression | EXP | | 6480464 | CTD | Dieldrin results in decreased expression of ESR1 protein | PMID:21278053 | Esr1 | multiple interactions | EXP | | 6480464 | CTD | Dieldrin inhibits the reaction [Estradiol binds to ESR1 protein] | PMID:21278053 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dieldrin binds to ESR1 protein | PMID:14579009 | Esr1 | increases activity | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Dieldrin results in increased activity of ESR1 protein | PMID:17174995 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dieldrin results in increased activity of ESR1 protein | PMID:15064155 PMID:26022396 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dieldrin results in increased expression of ESR1 mRNA | PMID:11922773 PMID:21295777 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Dieldrin co-treated with alachlor] inhibits the reaction [Estradiol binds to ESR1 protein]; [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; Dieldrin binds to and results in increased activity of ESR1 protein; Dieldrin inhibits the reaction [Estradiol binds to ESR1 protein]; Dieldrin inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA] | PMID:10774817 PMID:11922773 PMID:14579009 PMID:15261991 PMID:16626760 PMID:21295777 PMID:9168004 | |
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