Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDChlorpyrifos results in decreased expression of ESR1 proteinPMID:34571837 PMID:36769379
Esr1increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of ESR1 mRNAPMID:34571837
Esr1multiple interactionsEXP 6480464CTD[Chlorpyrifos co-treated with Triiodothyronine] results in increased expression of ESR1 mRNAPMID:34571837
Esr1affects expressionISOEsr1 (Rattus norvegicus)6480464CTDChlorpyrifos affects the expression of ESR1 mRNAPMID:34858468
Esr1decreases activityISOESR1 (Homo sapiens)6480464CTDChlorpyrifos results in decreased activity of ESR1 proteinPMID:22562034
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDChlorpyrifos results in decreased expression of ESR1 protein modified formPMID:26518068
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDChlorpyrifos results in decreased expression of ESR1 mRNAPMID:32171938
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDChlorpyrifos results in increased activity of ESR1 proteinPMID:15064155 PMID:26812056 PMID:28728110 PMID:32171938
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of ESR1 mRNAPMID:35457321
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[APOE gene polymorphism affects the susceptibility to Chlorpyrifos] which affects the expression of ESR1 mRNA; [Chlorpyrifos co-treated with fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [[Chlorpyrifos co-treated with Estradiol] results in increased activity of ESR1 protein]; Chlorpyrifos promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Chlorpyrifos results in increased activity of ESR1 protein]PMID:26812056 PMID:31472362 PMID:32171938
Go Back to source page   Continue to Ontology report