GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | increases expression | EXP | | 6480464 | CTD | 4,4'-bisphenol F results in increased expression of ESR1 mRNA | PMID:30196065 | Esr1 | affects binding | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | 4,4'-bisphenol F binds to ESR1 protein | PMID:27420082 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | bisphenol F binds to ESR1 protein | PMID:31836225 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | bisphenol F results in decreased expression of ESR1 protein | PMID:31995776 PMID:34831106 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | 4,4'-bisphenol F results in increased activity of ESR1 protein; bisphenol F results in increased activity of ESR1 protein | PMID:30582956 PMID:31388671 PMID:36534918 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | 4,4'-bisphenol F results in increased expression of ESR1 mRNA; 4,4'-bisphenol F results in increased expression of ESR1 protein | PMID:18973785 PMID:30195206 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | 4,4'-bisphenol F binds to and results in increased activity of ESR1 protein; 4,4'-bisphenol F inhibits the reaction [Estradiol binds to ESR1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [4,4'-bisphenol F results in increased expression of ESR1 protein]; [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of ESR1 protein; bisphenol F binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased expression of ESR1 protein] | PMID:15110108 PMID:28591870 PMID:29392883 PMID:30195206 PMID:31195007 PMID:31388671 PMID:31995776 | |
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