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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:3387
Term: carbamazepine
Definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Chemical ID: MESH:D002220
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases expressionEXP 6480464CTDCarbamazepine results in increased expression of ESR1 mRNAPMID:19490052
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDCarbamazepine results in decreased expression of ESR1 mRNA; Carbamazepine results in decreased expression of ESR1 proteinPMID:16965676
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of ESR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of ESR1 protein]PMID:16965676
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