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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:31669
Term: hexestrol
Definition: A stilbenoid that has formula C18H22O2.
Chemical ID: MESH:D006589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDHexestrol binds to ESR1 proteinPMID:19233257 PMID:20074635
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDafimoxifene inhibits the reaction [Hexestrol binds to and results in increased activity of ESR1 protein]; Hexestrol binds to and affects the activity of ESR1 protein; Hexestrol binds to and results in increased activity of ESR1 protein; Hexestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Hexestrol promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Hexestrol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Hexestrol promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]PMID:18976723 PMID:19233257 PMID:20362049 PMID:20435135 PMID:23383871 PMID:26865669 PMID:29162470 PMID:33049310 PMID:9048584
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