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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of ESR1 mRNA; Benzo(a)pyrene results in decreased expression of ESR1 proteinPMID:19770486 PMID:26149760
Esr1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of ESR1 mRNAPMID:22228805
Esr1multiple interactionsEXP 6480464CTDBenzo(a)pyrene inhibits the reaction [NR2E3 protein binds to ESR1 promoter]; Benzo(a)pyrene promotes the reaction [KDM1A protein binds to ESR1 promoter]PMID:26149760
Esr1affects activityISOESR1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the activity of ESR1 proteinPMID:20624995
Esr1affects methylationISOESR1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ESR1 5' UTR; Benzo(a)pyrene affects the methylation of ESR1 intron; Benzo(a)pyrene affects the methylation of ESR1 promoterPMID:27901495 PMID:30157460
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of ESR1 mRNA; Benzo(a)pyrene results in decreased expression of ESR1 proteinPMID:17583486 PMID:18634860 PMID:34283317
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ESR1 mRNA; Benzo(a)pyrene results in decreased expression of ESR1 proteinPMID:26149760
Esr1decreases methylationISOESR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ESR1 3' UTRPMID:27901495
Esr1decreases response to substanceISOESR1 (Homo sapiens)6480464CTDESR1 protein results in decreased susceptibility to Benzo(a)pyrenePMID:21920623
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased activity of ESR1 proteinPMID:26022396 PMID:28728110
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ESR1 mRNAPMID:11922773 PMID:22316170
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene affects the reaction [Ethinyl Estradiol results in decreased expression of ESR1 protein]PMID:17583486
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with chrysene] results in increased expression of ESR1 mRNA; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of ESR1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Estradiol binds to ESR1 protein]]; Benzo(a)pyrene binds to and results in increased activity of ESR1 protein; Benzo(a)pyrene inhibits the reaction [Coumestrol binds to ESR1 protein modified form]; Benzo(a)pyrene inhibits the reaction [Estradiol binds to ESR1 protein]; Benzo(a)pyrene inhibits the reaction [NR2E3 protein binds to ESR1 promoter]; Benzo(a)pyrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; Benzo(a)pyrene promotes the reaction [ESR1 protein binds to TFF1 promoter]; Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Benzo(a)pyrene promotes the reaction [KDM1A protein binds to ESR1 promoter]; Benzo(a)pyrene promotes the reaction [SIN3A protein binds to ESR1 promoter]; fulvestrant inhibits the reaction [Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; S-ethyl glutathione inhibits the reaction [Benzo(a)pyrene results in decreased expression of ESR1 protein]PMID:11922773 PMID:12441364 PMID:15253042 PMID:16972788 PMID:26149760 PMID:28009930 PMID:29152682
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