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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ESR1 protein]PMID:32402895
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of ESR1 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR1 mRNA]PMID:18829485 PMID:26149760
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