A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID:
MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Genistein results in decreased expression of ESR1; Genistein results in decreased expression of ESR1 mRNA; Genistein results in decreased expression of ESR1 protein
[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of ESR1 mRNA; [Genistein co-treated with Isoflavones] results in decreased expression of ESR1 mRNA; [Genistein co-treated with Methoxychlor] results in increased expression of ESR1 mRNA; [Methoxychlor co-treated with Genistein] results in increased expression of ESR1 protein; Genistein affects the reaction [Oxygen deficiency affects the expression of ESR1 mRNA]; Genistein affects the reaction [Oxygen deficiency affects the expression of ESR1 protein]; Genistein inhibits the reaction [Estradiol affects the expression of ESR1 mRNA]; Genistein inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA]
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Genistein binds to and results in increased activity of ESR1 protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Genistein binds to and results in increased activity of ESR1 protein]; [afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Genistein; [Estradiol co-treated with Genistein co-treated with o,p'-DDT] affects the expression of ESR1 mRNA; [Fulvestrant binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Genistein; [Genistein binds to ESR1 protein] which results in increased activity of ALPL protein; [Genistein co-treated with ESR1 protein] results in decreased expression of EGFR mRNA; [Genistein co-treated with ESR1 protein] results in decreased expression of EGFR protein; [Genistein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA; [Genistein co-treated with ESR1 protein] results in increased expression of LTF mRNA; [Genistein co-treated with ESR1] results in increased expression of BSP mRNA; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; ESR1 mutant form inhibits the reaction [Genistein inhibits the reaction [Dexamethasone results in increased expression of LEFTY1 mRNA]]; ESR1 mutant form inhibits the reaction [Genistein inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]]; ESR1 mutant form inhibits the reaction [Genistein results in increased expression of AGT mRNA]; ESR1 mutant form inhibits the reaction [Genistein results in increased expression of CA12 mRNA]; ESR1 mutant form inhibits the reaction [Genistein results in increased expression of NPPC mRNA]; ESR1 promotes the reaction [Genistein results in decreased expression of ACTBL2 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of APLP2 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of BCKDHA protein]; ESR1 promotes the reaction [Genistein results in decreased expression of CHCHD1 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of CHMP2B protein]; ESR1 promotes the reaction [Genistein results in decreased expression of HMGN1 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of HNRNPC protein]; ESR1 promotes the reaction [Genistein results in decreased expression of KPRP protein]; ESR1 promotes the reaction [Genistein results in decreased expression of LGALS7 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of LMNA protein]; ESR1 promotes the reaction [Genistein results in decreased expression of LMNB1 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of LPP protein]; ESR1 promotes the reaction [Genistein results in decreased expression of MAP4 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of MOGS protein]; ESR1 promotes the reaction [Genistein results in decreased expression of MYO15A protein]; ESR1 promotes the reaction [Genistein results in decreased expression of NASP protein]; ESR1 promotes the reaction [Genistein results in decreased expression of NFS1 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of NLN protein]; ESR1 promotes the reaction [Genistein results in decreased expression of NPC2 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of PIP protein]; ESR1 promotes the reaction [Genistein results in decreased expression of PNKD protein]; ESR1 promotes the reaction [Genistein results in decreased expression of POFUT1 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of RPS16 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of RPS18 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of RPS25 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of RPS29 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of S100A8 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of S100A9 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of SEPHS1 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of SYAP1 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of THOC2 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of TIMM10B protein]; ESR1 promotes the reaction [Genistein results in decreased expression of TOMM40 protein]; ESR1 promotes the reaction [Genistein results in decreased expression of TPR protein]; ESR1 promotes the reaction [Genistein results in decreased expression of VAT1 protein]; ESR1 promotes the reaction [Genistein results in increased expression of ASNS protein]; ESR1 promotes the reaction [Genistein results in increased expression of CCDC25 protein]; ESR1 promotes the reaction [Genistein results in increased expression of KRT18 protein]; ESR1 promotes the reaction [Genistein results in increased expression of KRT19 protein]; ESR1 promotes the reaction [Genistein results in increased expression of KRT8 protein]; ESR1 promotes the reaction [Genistein results in increased expression of MGP protein]; ESR1 promotes the reaction [Genistein results in increased expression of MRPL20 protein]; ESR1 promotes the reaction [Genistein results in increased expression of MYH10 protein]; ESR1 promotes the reaction [Genistein results in increased expression of MYH14 protein]; ESR1 promotes the reaction [Genistein results in increased expression of MYH9 protein]; ESR1 promotes the reaction [Genistein results in increased expression of MYL12B protein]; ESR1 promotes the reaction [Genistein results in increased expression of MYL6 protein]; ESR1 promotes the reaction [Genistein results in increased expression of NBN protein]; ESR1 promotes the reaction [Genistein results in increased expression of NFAT5 protein]; ESR1 promotes the reaction [Genistein results in increased expression of NIBAN1 protein]; ESR1 promotes the reaction [Genistein results in increased expression of NPM1 protein]; ESR1 promotes the reaction [Genistein results in increased expression of RCN1 protein]; ESR1 promotes the reaction [Genistein results in increased expression of RPL23AP37 protein]; ESR1 promotes the reaction [Genistein results in increased expression of SLC3A2 protein]; ESR1 promotes the reaction [Genistein results in increased expression of SLC7A5 protein]; ESR1 promotes the reaction [Genistein results in increased expression of TMEM120A protein]; ESR1 promotes the reaction [Genistein results in increased expression of TTBK2 protein]; ESR1 protein inhibits the reaction [Genistein results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Genistein results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [Genistein results in increased expression of PRSS23 mRNA]; ESR1 protein inhibits the reaction [Genistein results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [Genistein results in increased activity of ESR1 protein]; Genistein binds to and results in increased activity of ESR1 protein; Genistein inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Genistein inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Genistein inhibits the reaction [Estradiol binds to ESR1 protein]; Genistein inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Genistein inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Genistein inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Genistein promotes the reaction [BID protein binds to ESR1 protein]; Genistein promotes the reaction [ESR1 protein binds to ESR1 protein]; Genistein promotes the reaction [ESR1 protein binds to GREB1 promoter]; Genistein promotes the reaction [ESR1 protein binds to JUND promoter]; Genistein promotes the reaction [ESR1 protein binds to NCOA1 protein]; Genistein promotes the reaction [ESR1 protein binds to NCOA2 protein]; Genistein promotes the reaction [ESR1 protein binds to TSC22D3 promoter]; Genistein promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Genistein promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]; Genistein promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Genistein promotes the reaction [H1-3 protein binds to ESR1 protein]; Genistein promotes the reaction [HSP90AB2P protein binds to ESR1 protein]; Genistein promotes the reaction [KHDRBS2 protein binds to ESR1 protein]; Genistein promotes the reaction [KRT78 protein binds to ESR1 protein]; Genistein promotes the reaction [NCOA1 protein binds to ESR1 protein]; Genistein promotes the reaction [NCOA2 protein binds to ESR1 protein]; Genistein promotes the reaction [NCOA3 protein binds to ESR1 protein]; Genistein promotes the reaction [NELFE protein binds to ESR1 protein]; Genistein promotes the reaction [RPS20 protein binds to ESR1 protein]; Genistein promotes the reaction [TMEM205 protein binds to ESR1 protein]; Genistein promotes the reaction [TSPYL5 protein binds to ESR1 protein]; Methoxychlor metabolite inhibits the reaction [Genistein binds to and results in increased activity of ESR1 protein]; Methoxychlor metabolite promotes the reaction [Genistein binds to and results in increased activity of ESR1 protein]; RU 58668 promotes the reaction [Fulvestrant inhibits the reaction [Genistein results in increased activity of ESR1 protein]]
