Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:27086
Term: tributylstannane
Definition: An organotin compound that has formula C12H28Sn.
Chemical ID: MESH:C011559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDtributyltin results in decreased expression of ESR1 proteinPMID:25819109 PMID:32239163
Esr1multiple interactionsEXP 6480464CTDEstrogens inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; fulvestrant inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; tributyltin inhibits the reaction [Estrogens results in increased expression of ESR1 protein]PMID:25819109
Esr1affects expressionISOEsr1 (Rattus norvegicus)6480464CTDtributyltin affects the expression of ESR1 proteinPMID:25819109
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDtributyltin results in decreased expression of ESR1 proteinPMID:27521499 PMID:28161095 PMID:29908848
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDtributyltin results in increased expression of ESR1 mRNAPMID:23523586
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDfulvestrant inhibits the reaction [tributyltin affects the expression of ESR1 protein]PMID:25819109
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDtributyltin binds to and results in increased activity of ESR1 protein; tributyltin results in increased expression of and affects the localization of ESR1 proteinPMID:23523586
Go Back to source page   Continue to Ontology report