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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:17642
Term: pentachlorophenol
Definition: A chlorophenol that is phenol substituted by 5 chloro groups.
Chemical ID: MESH:D010416
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDPentachlorophenol binds to ESR1 proteinPMID:15081572
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDPentachlorophenol binds to and results in decreased activity of ESR1 protein; Pentachlorophenol inhibits the reaction [Estradiol binds to ESR1 protein]PMID:15081572 PMID:16626760
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