Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Estradiol results in increased expression of ESR1 mRNA; Estradiol results in increased expression of ESR1 mRNA alternative form; Estradiol results in increased expression of ESR1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; 4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; [bisphenol A results in increased phosphorylation of ESR1 protein] which results in increased activity of Estradiol; [Bromocriptine co-treated with Estradiol] results in increased expression of ESR1 protein; [desmethylarzoxifene co-treated with Estradiol] results in decreased expression of ESR1 protein; [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of ESR1 mRNA; [Estradiol co-treated with bisindolylmaleimide I] results in increased expression of ESR1 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of ESR1 mRNA; [Estradiol co-treated with PRL protein] results in increased expression of ESR1 protein; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ESR1 protein; [Metoclopramide co-treated with Estradiol] results in decreased expression of ESR1 protein; [Polyphenols co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of ESR1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]; bisphenol A inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; bu-zhong-yi-qi-tang inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Dieldrin inhibits the reaction [Estradiol binds to ESR1 protein]; Endosulfan inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 affects the reaction [Estradiol results in decreased expression of LHB protein]; ESR1 affects the reaction [Estradiol results in increased expression of ESR1 mRNA alternative form]; ESR1 affects the reaction [Estradiol results in increased expression of FOS mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of CYP17A1 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of AURKB mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of CCNB2 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of FOS mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of G6PDX mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of INHBB mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of INS2 protein]; ESR1 protein affects the reaction [Estradiol results in increased expression of LTF mRNA]; ESR1 protein mutant form inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]; ESR1 protein mutant form inhibits the reaction [Estradiol results in increased expression of STAT5A mRNA]; ESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA]; ESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LIF mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of APOE mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of DKK2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of EDN3 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of ETS1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of FZD10 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of FZD7 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of HMGA2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of ID2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of IGF1R mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of IL7R mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of LEF1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of MAP2K6 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of MAP2K7 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of NGF mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of NTRK2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of PIK3R1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of PTX3 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of SOX17 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of THBS1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of THRB mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of TLE1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of ANLN mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of AURKA mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of BIRC5 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of BUB1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CCN1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CCNA2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CCNE1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDC20 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDC25C mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDC7 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDCA5 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDCA8 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDH3 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDK2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CDKN1A mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CENPA mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CENPE mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CENPF mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CENPH mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CHEK1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CHEK2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CHN2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CIT mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CKAP2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CSNK1A1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CSNK1G3 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of DBF4 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of E2F1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of E2F2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of E2F3 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of EGFR mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of ERRFI1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of ESCO2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of ESPL1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FGFR2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FGFR3 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FOS mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of GJA1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of GMNN mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of HELLS mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of KIF11 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of KIF15 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of KIF22 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of KIF2C mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of KIF4A mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of KIFC1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of KLK1B5 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of MAD2L1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of MAP2K1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of MASTL mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of MCM2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of MYBL2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of NEK2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of NR4A1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of NUBP1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of NUSAP1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of PLK1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of PLK4 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of PPP2R2C mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of RCC1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of SERPINB5 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of SGO1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of SOX11 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of SOX9 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of STAT3 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of STIL mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of TOP2A mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of TPX2 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of WNT10A mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of WNT10B mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of WNT7B mRNA]; ESR2 affects the reaction [Estradiol results in decreased expression of ESR1 protein]; Estradiol binds to and affects the transport of ESR1 protein; Estradiol binds to and results in increased activity of ESR1 protein; Estradiol inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; Estradiol inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [[ESR1 protein binds to STAT5A promoter] which results in increased expression of STAT5A mRNA]; Estradiol promotes the reaction [ESR1 protein binds to CCND1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to CDKN1A promoter]; Estradiol promotes the reaction [ESR1 protein binds to FOS promoter]; Estradiol promotes the reaction [ESR1 protein binds to IGF1 promoter]; Fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; Fulvestrant inhibits the reaction [Estradiol binds to and affects the transport of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Fulvestrant promotes the reaction [Estradiol results in increased expression of ESR1 protein]; Progesterone inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; SB 203580 inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Tamoxifen promotes the reaction [Estradiol results in increased expression of ESR1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Estradiol results in increased expression of ESR1 protein]; Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]
[Estradiol binds to ESR1 protein] which binds to NCOA2 protein; Estradiol analog binds to ESR1 protein; Estradiol binds to ESR1 protein; Estradiol metabolite binds to ESR1 protein; perfluorobutanesulfonic acid binds to [ESR1 protein binds to Estradiol]; perfluorobutyric acid binds to [ESR1 protein binds to Estradiol]; perfluorohexanesulfonic acid binds to [ESR1 protein binds to Estradiol]; perfluorooctane sulfonic acid binds to [ESR1 protein binds to Estradiol]; perfluoropentanoic acid binds to [ESR1 protein binds to Estradiol]
Estradiol results in decreased expression of ESR1 mRNA; Estradiol results in decreased expression of ESR1 mRNA alternative form; Estradiol results in decreased expression of ESR1 protein
Estradiol results in decreased expression of ESR1; Estradiol results in decreased expression of ESR1 mRNA; Estradiol results in decreased expression of ESR1 protein
Estradiol analog results in increased activity of ESR1 protein; Estradiol results in increased activity of ESR1; Estradiol results in increased activity of ESR1 protein; Estradiol results in increased activity of ESR1 protein mutant form
Estradiol results in increased expression of ESR1 mRNA; Estradiol results in increased expression of ESR1 protein; Estradiol results in increased expression of ESR1 protein alternative form
Estradiol results in increased expression of ESR1 mRNA; Estradiol results in increased expression of ESR1 protein; Estradiol results in increased expression of ESR1 protein alternative form
3-phenoxybenzoic acid inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein]; [Estradiol binds to ESR1 protein] which affects the localization of KLF4 protein; [Estradiol binds to ESR1 protein] which results in increased expression of KLF4; [Estradiol co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of ESR1 protein; [Estradiol co-treated with ormeloxifene] promotes the reaction [NCOR1 protein binds to ESR1 protein]; [Estradiol co-treated with ormeloxifene] promotes the reaction [NRIP1 protein binds to ESR1 protein]; [Estradiol co-treated with ormeloxifene] results in decreased expression of ESR1 protein; [Estradiol co-treated with Progesterone] results in decreased expression of ESR1 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of ESR1 mRNA alternative form; [Estradiol co-treated with Progesterone] results in increased expression of ESR1 mRNA; [Permethrin co-treated with Estradiol] results in decreased expression of ESR1; alpha-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]; Atrazine inhibits the reaction [Estradiol binds to ESR1 protein]; bisphenol A inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein]; bisphenol A inhibits the reaction [Estradiol binds to ESR1 protein]; butylparaben inhibits the reaction [Estradiol binds to ESR1 protein]; Cadmium Chloride promotes the reaction [Estradiol results in increased expression of ESR1 mRNA]; Cadmium promotes the reaction [Estradiol results in increased expression of ESR1 mRNA]; cypermethrin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; dibromoacetic acid inhibits the reaction [Estradiol binds to ESR1 protein]; Diethylstilbestrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein]; Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein results in decreased susceptibility to [Estradiol co-treated with ESR2 protein]; Estradiol affects the reaction [Oxygen deficiency affects the expression of ESR1 mRNA]; Estradiol affects the reaction [Oxygen deficiency affects the expression of ESR1 protein]; Estradiol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [Cadmium Chloride results in increased expression of ESR1 mRNA]; Estradiol promotes the reaction [Cadmium results in increased expression of ESR1 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]; Estradiol promotes the reaction [ESR2 protein alternative form binds to ESR1 protein]; fipronil inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Genistein inhibits the reaction [Estradiol affects the expression of ESR1 mRNA]; Heptachlor inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein]; Mitotane inhibits the reaction [Estradiol binds to ESR1 protein]; Mitotane inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; o,p'-DDT inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; ormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]; Pesticides inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Progesterone inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Soil Pollutants inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]; TS 108 inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
(+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 promoter]]; 1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]; 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [Estradiol binds to ESR1 protein]; 1-benzylpiperidine inhibits the reaction [Estradiol binds to ESR1 protein]; 16 alpha-bromo-17 beta-estradiol inhibits the reaction [Estradiol binds to ESR1 protein]; 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol binds to ESR1 protein]; 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Estradiol binds to ESR1 protein]; 2,4-dihydroxybenzophenone inhibits the reaction [Estradiol binds to ESR1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; 2-amino-(1,6-dimethylfuro(3,2-e)imidazo(4,5-b))pyridine inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 2-ethyl-4-(4-hydroxyphenyl)-5-(4-(2-piperidin-1-ylethoxy)phenyl)-2-imidazoline inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 2-methylquinoline analog inhibits the reaction [Estradiol binds to ESR1 protein]; 2-methylquinoline inhibits the reaction [Estradiol binds to ESR1 protein]; 22-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide inhibits the reaction [Estradiol binds to ESR1 protein]; 3-hydroxybisphenol A inhibits the reaction [Estradiol binds to ESR1 protein]; 3-methylquinoline inhibits the reaction [Estradiol binds to ESR1 protein]; 3-phenoxybenzoic acid inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; 4,17 beta-dihydroxy-4-androstene-3-one inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; 4,4'-bisphenol F inhibits the reaction [Estradiol binds to ESR1 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Estradiol binds to ESR1 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 4,4'-thiobis(6-tert-butyl-3-cresol) inhibits the reaction [Estradiol binds to ESR1 protein]; 4-(3',5'-dimethyl 3'-heptyl)phenol affects the reaction [Estradiol results in increased activity of ESR1 protein]; 4-(3',6'-dimethyl-3'-heptyl)phenol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 4-hydroxybenzophenone inhibits the reaction [Estradiol binds to ESR1 protein]; 4-hydroxyquinoline inhibits the reaction [Estradiol binds to ESR1 protein]; 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene affects the reaction [Estradiol binds to ESR1 protein]; 4-nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; 4-tert-octylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; 6-deisopropylatrazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 6-hydroxyquinoline inhibits the reaction [Estradiol binds to ESR1 protein]; 6-prenylnaringenin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; 8-methylquinoline inhibits the reaction [Estradiol binds to ESR1 protein]; [(all-E) phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; [afimoxifene results in decreased susceptibility to Estradiol] which results in decreased expression of ESR1 protein modified form; [AHR protein binds to ESR1 protein] affects the reaction [Estradiol results in increased expression of BRCA1 mRNA]; [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; [Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased susceptibility to Estradiol; [Chlorpyrifos co-treated with fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein; [Dieldrin co-treated with alachlor] inhibits the reaction [Estradiol binds to ESR1 protein]; [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; [Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein; [Estradiol results in increased activity of ESR1 protein] which results in decreased expression of GABRP mRNA; [Estradiol results in increased activity of ESR1 protein] which results in decreased expression of GSN mRNA; [Estradiol results in increased activity of ESR1 protein] which results in increased expression of BCL2 mRNA; [Estradiol results in increased activity of ESR1 protein] which results in increased expression of CCND1 mRNA; [Estradiol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [Estradiol results in increased activity of ESR1 protein] which results in increased expression of IGFBP4 mRNA; [Estradiol results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA; [Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB9 mRNA; [Estradiol results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [Estradiol results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [Estradiol results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA; [fludioxonil co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of ESR1 protein; [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Estradiol; [Tamoxifen co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein]; [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]; [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; Acetaminophen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]]; afimoxifene inhibits the reaction [[Chlorpyrifos co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; AG 1879 inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]]; AHR gene mutant form promotes the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to TFF1 promoter]]; AHR gene mutant form promotes the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; alachlor inhibits the reaction [Estradiol binds to ESR1 protein]; Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Aldrin inhibits the reaction [Estradiol binds to ESR1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Estradiol binds to ESR1 protein]]; anethole metabolite inhibits the reaction [Estradiol binds to ESR1 protein]; angelicae sinensis extract inhibits the reaction [Estradiol binds to ESR1 protein]; Apigenin inhibits the reaction [Estradiol binds to ESR1 protein]; ARID5A protein inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]]; Arsenic Trioxide promotes the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Arsenic Trioxide promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; arsenite inhibits the reaction [Estradiol binds to ESR1 protein]; Atrazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Atrazine inhibits the reaction [Estradiol binds to ESR1 protein]; bendiocarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Benomyl inhibits the reaction [Estradiol binds to ESR1 protein]; benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased localization of ESR1 protein]; Benzene Derivatives analog inhibits the reaction [Estradiol binds to ESR1 protein]; Benzo(a)pyrene inhibits the reaction [Estradiol binds to ESR1 protein]; Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]; benzyl benzoate inhibits the reaction [Estradiol binds to ESR1 protein]; benzyl salicylate inhibits the reaction [Estradiol binds to ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; biochanin A inhibits the reaction [Estradiol binds to ESR1 protein]; bisphenol A analog inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; bisphenol A inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; bisphenol A inhibits the reaction [Estradiol binds to ESR1 protein]; bisphenol A inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; bisphenol B inhibits the reaction [Estradiol binds to ESR1 protein]; Bortezomib inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; BRCA1 protein affects the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; Butylated Hydroxyanisole inhibits the reaction [Estradiol binds to ESR1 protein]; butylbenzyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of CCND1 mRNA]; Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB9 mRNA]; Cadmium Chloride promotes the reaction [Estradiol results in increased activity of ESR1 protein]; carbamylhydrazine inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; CCND1 protein promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein]; chlormidazole inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Chlorpyrifos promotes the reaction [Estradiol results in increased activity of ESR1 protein]; chromous chloride inhibits the reaction [Estradiol binds to ESR1 protein]; citral inhibits the reaction [Estradiol binds to ESR1 protein]; cobaltous chloride inhibits the reaction [Estradiol binds to ESR1 protein]; cobaltous chloride promotes the reaction [Estradiol results in decreased expression of ESR1 mRNA]; cobaltous chloride promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Coumestrol inhibits the reaction [Estradiol binds to ESR1 protein]; cupric chloride inhibits the reaction [Estradiol binds to ESR1 protein]; cupric chloride promotes the reaction [Estradiol results in decreased expression of ESR1 mRNA]; cupric chloride promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; cyanazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; daidzein inhibits the reaction [Estradiol binds to ESR1 protein]; daidzein promotes the reaction [Estradiol results in increased activity of ESR1 protein]; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; di-n-octyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; di-n-pentyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; DIBA-1 inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Dibutyl Phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Estradiol binds to ESR1 protein]; dicyclohexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Dieldrin inhibits the reaction [Estradiol binds to ESR1 protein]; Dieldrin inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Diethylhexyl Phthalate inhibits the reaction [Estradiol binds to ESR1 protein]; Diethylhexyl Phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein]; Dihydrotestosterone inhibits the reaction [Estradiol binds to ESR1 protein]; diisobutyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; diisononyl 1,2-cyclohexanedicarboxylic acid inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; diisononyl 1,2-cyclohexanedicarboxylic acid metabolite affects the reaction [Estradiol results in increased activity of ESR1 protein]; diisononyl 1,2-cyclohexanedicarboxylic acid metabolite inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; diisononyl 1,2-cyclohexanedicarboxylic acid metabolite promotes the reaction [Estradiol results in increased activity of ESR1 protein]; diisononyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Drugs, Chinese Herbal inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Endosulfan inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 affects the reaction [Estradiol results in increased expression of KRT19 mRNA]; ESR1 affects the reaction [Estradiol results in increased expression of TFF1 mRNA]; ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; ESR1 mutant form inhibits the reaction [Estradiol inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]]; ESR1 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; ESR1 mutant form inhibits the reaction [Estradiol results in increased expression of AGT mRNA]; ESR1 mutant form inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA]; ESR1 mutant form inhibits the reaction [Estradiol results in increased expression of NPPC mRNA]; ESR1 promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]; ESR1 promotes the reaction [Estradiol results in increased expression of PGR mRNA]; ESR1 promotes the reaction [Estradiol results in increased expression of TFF1 mRNA]; ESR1 protein affects the reaction [Estradiol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to H19 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to LLGL2 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to TMEM121B gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to H19 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to KLRC1 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to LLGL2 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to NKD1 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to H19 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to KLRC1 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to NKD1 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to SPATA13 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to TMEM121B gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TFF1 promoter]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]]; ESR1 protein affects the reaction [Estradiol results in decreased activity of CCL2 protein]; ESR1 protein affects the reaction [Estradiol results in decreased chemical synthesis of Superoxides]; ESR1 protein affects the reaction [Estradiol results in decreased expression of ABCB1 protein]; ESR1 protein affects the reaction [Estradiol results in decreased expression of ATP2A3 mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of CEACAM3 mRNA]; Estradiol promotes the reaction [Vanadates results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [VIM protein binds to ESR1 protein]; Estradiol results in increased activity of [ESR1 protein co-treated with ESR2 protein]; Estradiol results in increased activity of and affects the localization of ESR1 protein; Estradiol results in increased activity of and results in increased localization of ESR1 protein; Estradiol results in increased expression of and results in increased phosphorylation of ESR1 protein; Estradiol results in increased phosphorylation of and results in increased activity of and results in increased degradation of ESR1 protein; Estradiol results in increased phosphorylation of and results in increased localization of ESR1 protein; Estriol inhibits the reaction [Estradiol binds to ESR1 protein]; Estrone inhibits the reaction [Estradiol binds to ESR1 protein]; Ethinyl Estradiol inhibits the reaction [Estradiol binds to ESR1 protein]; Etoposide inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Eugenol inhibits the reaction [Estradiol binds to ESR1 protein]; fenarimol promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; FKBPL protein inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; fludioxonil inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]; fluorene-9-bisphenol inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; fluorene-9-bisphenol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; fluoxastrobin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; FOXA1 protein affects the reaction [[Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA]; FOXA1 protein affects the reaction [Estradiol affects the activity of ESR1 protein]; FOXA1 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA]]; Fulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant inhibits the reaction [Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant inhibits the reaction [Estradiol affects the localization of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Fulvestrant inhibits the reaction [fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; Genistein inhibits the reaction [Estradiol binds to ESR1 protein]; Genistein inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Genistein inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Genistein inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Genistein promotes the reaction [Estradiol results in increased activity of ESR1 protein]; geraniol inhibits the reaction [Estradiol binds to ESR1 protein]; glyceollin inhibits the reaction [Estradiol binds to ESR1 protein]; glycitein inhibits the reaction [Estradiol binds to ESR1 protein]; GW 7604 analog inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; GW 7604 inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; hexabrominated diphenyl ether 153 inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]; Hexachlorophene inhibits the reaction [Estradiol binds to ESR1 protein]; hydroxyflutamide inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein]; hyperoside inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; IGF1R mutant form inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SHC1 protein]]; IGF1R mutant form inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; kaempferol inhibits the reaction [Estradiol binds to ESR1 protein]; KRT18 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; KRT8 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; lead chloride inhibits the reaction [Estradiol binds to ESR1 protein]; lead chloride promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; leptomycin B inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Lithium Chloride inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Lithium Chloride inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Luteolin inhibits the reaction [Estradiol binds to ESR1 protein]; Lycopene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Mercuric Chloride inhibits the reaction [Estradiol binds to ESR1 protein]; Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Methomyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; methoxyacetic acid inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein]; Methoxychlor inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to HOXA10 gene]]; methylselenic acid inhibits the reaction [Estradiol binds to ESR1 protein]; metoprine inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Mitotane inhibits the reaction [Estradiol binds to ESR1 protein]; mono-benzyl phthalate promotes the reaction [Estradiol results in increased activity of ESR1 protein]; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; naringenin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; NCOA2 protein promotes the reaction [Estradiol results in increased activity of ESR1 protein]; nickel chloride inhibits the reaction [Estradiol binds to ESR1 protein]; nonachlor inhibits the reaction [Estradiol binds to ESR1 protein]; nonylphenol analog inhibits the reaction [Estradiol binds to ESR1 protein]; nonylphenol analog inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein]; o,p'-DDT promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Ospemifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Oxygen deficiency promotes the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Oxygen deficiency promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Particulate Matter analog inhibits the reaction [Estradiol binds to ESR1 protein]; Pentachlorophenol inhibits the reaction [Estradiol binds to ESR1 protein]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; phthalic acid analog inhibits the reaction [Estradiol binds to ESR1 protein]; Plant Extracts inhibits the reaction [Estradiol binds to ESR1 protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Polychlorinated Biphenyls metabolite inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Polyphenols inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; prochloraz inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Propolis inhibits the reaction [Estradiol binds to ESR1 protein]; Propoxur inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; pyridaben inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; pyridate inhibits the reaction [Estradiol binds to ESR1 protein]; Quercetin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; quinoline inhibits the reaction [Estradiol binds to ESR1 protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol binds to ESR1 protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Resveratrol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Resveratrol inhibits the reaction [Estradiol binds to ESR1 protein]; Resveratrol inhibits the reaction [Estradiol promotes the reaction [ESR1 results in increased expression of CYP19A1 mRNA alternative form]]; Resveratrol inhibits the reaction [Estradiol promotes the reaction [ESR1 results in increased expression of CYP19A1 protein]]; Resveratrol inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Resveratrol inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Resveratrol promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Rotenone inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]; RU 58668 inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Santowhite powder inhibits the reaction [Estradiol binds to ESR1 protein]; SB 203580 promotes the reaction [Estradiol results in increased degradation of ESR1 protein]; Simazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; sodium arsenite affects the reaction [Estradiol affects the expression of ESR1 mRNA]; sodium arsenite affects the reaction [Estradiol affects the expression of ESR1 protein]; ST 1481 inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; stannous chloride inhibits the reaction [Estradiol binds to ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol binds to ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to AICDA promoter]]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]]; Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Tamoxifen promotes the reaction [Estradiol results in increased activity of ESR1 protein mutant form]; TBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]]; TBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]]; Tetrachlorodibenzodioxin inhibits the reaction [[Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol binds to ESR1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased degradation of ESR1 protein]; TGFB3 protein inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Topotecan inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Toxaphene inhibits the reaction [Estradiol binds to ESR1 protein]; tri-(2-ethylhexyl)trimellitate promotes the reaction [Estradiol results in increased activity of ESR1 protein]; trichostatin A promotes the reaction [Estradiol results in decreased expression of ESR1 mRNA]; triclocarban analog promotes the reaction [Estradiol results in increased activity of ESR1 protein]; triclocarban promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Triclosan inhibits the reaction [Estradiol binds to ESR1 protein]; Triclosan inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; trifloxystrobin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; U 0126 inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Valproic Acid metabolite promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Valproic Acid promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Vanadates inhibits the reaction [Estradiol binds to ESR1 protein]; Vanadates promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Vehicle Emissions analog inhibits the reaction [Estradiol binds to ESR1 protein]; vinclozolin inhibits the reaction [Estradiol binds to ESR1 protein]; Vitamin K 3 inhibits the reaction [Estradiol binds to ESR1 protein]; Vorinostat inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Water Pollutants, Chemical inhibits the reaction [Estradiol results in increased activity of ESR1]; xanthohumol promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; ZNF366 protein inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
[ESR1 protein co-treated with MED25 protein co-treated with Estradiol] results in increased activity of CYP2C9 protein; [ESR1 protein co-treated with MED25 protein co-treated with Estradiol] results in increased expression of CYP2C9 mRNA; [ESR1 protein results in increased susceptibility to Estradiol] inhibits the reaction [Fenofibrate results in decreased expression of CASP3 protein]; [ESR1 protein results in increased susceptibility to Estradiol] which results in increased abundance of Superoxides; [Estradiol binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; [Estradiol binds to ESR1 protein] which affects the folding of ESR1 protein; [Estradiol binds to ESR1 protein] which results in decreased expression of ABCG2; [Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA; [Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein; [Estradiol co-treated with (+)-JQ1 compound] results in decreased expression of ESR1 mRNA; [Estradiol co-treated with (+)-JQ1 compound] results in decreased expression of ESR1 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in increased expression of ESR1 protein; [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of ESR1 mRNA; [Estradiol co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [Estradiol co-treated with Dexamethasone] results in decreased expression of ESR1 mRNA; [Estradiol co-treated with Dexamethasone] results in decreased expression of ESR1 protein; [Estradiol co-treated with ESR1 protein] promotes the reaction [ESR1 protein binds to BTRC protein]; [Estradiol co-treated with ESR1 protein] results in decreased expression of EGFR mRNA; [Estradiol co-treated with ESR1 protein] results in decreased expression of EGFR protein; [Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein; [Estradiol co-treated with ESR1 protein] results in increased expression of BGLAP mRNA; [Estradiol co-treated with ESR1 protein] results in increased expression of BSP mRNA; [Estradiol co-treated with ESR1 protein] results in increased expression of HSP90B1 protein; [Estradiol co-treated with ESR1 protein] results in increased expression of HSPA5 protein; [Estradiol co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Estradiol co-treated with ESR1 protein] results in increased expression of LTF mRNA; [Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA; [Estradiol co-treated with ESR1 protein] results in increased expression of PTGS2 mRNA; [Estradiol co-treated with ESR1 protein] results in increased phosphorylation of AKT1 protein; [Estradiol co-treated with ESR1 protein] results in increased phosphorylation of MAPK1 protein; [Estradiol co-treated with ESR1] results in increased expression of MCP1 mRNA; [Estradiol co-treated with ESR1] results in increased expression of NOS2 mRNA; [Estradiol co-treated with ESR1] results in increased expression of NOS3 mRNA; [Estradiol co-treated with ESR1] results in increased expression of TIMP1 mRNA; [Estradiol co-treated with Fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Estradiol co-treated with Genistein co-treated with o,p'-DDT] affects the expression of ESR1 mRNA; [Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]; [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to GREB1 promoter]; [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to TFF1 promoter]; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of and results in increased degradation of ESR1 protein; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased ubiquitination of ESR1 protein; [Estradiol co-treated with TGFB1 protein] results in decreased expression of ESR1 mRNA; ESR1 protein affects the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]; ESR1 protein affects the reaction [Estradiol results in decreased expression of EIF5A mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of ELAC2 mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of EMP1 mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of ETFB mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of HAS2 mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of PTPRO mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of SEC16A mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased secretion of IL6 protein]; ESR1 protein affects the reaction [Estradiol results in increased expression of AGT mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of BCL2 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of BCL2 protein]; ESR1 protein affects the reaction [Estradiol results in increased expression of CCKBR mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of CCN5 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of CYCS protein]; ESR1 protein affects the reaction [Estradiol results in increased expression of E2F1 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of GPR176 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of GREB1 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of HOXC6 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of HSP90AB1 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of KRT19 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of MYBL1 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of PDCD4 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of PDCD4 protein]; ESR1 protein affects the reaction [Estradiol results in increased expression of PIP5K1A mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of PTEN mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of PTEN protein]; ESR1 protein affects the reaction [Estradiol results in increased expression of SERPINA1 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of SGK1 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of TGM2 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased phosphorylation of HSF1 protein]; ESR1 protein alternative form affects the reaction [Estradiol results in increased activity of MMP2 protein]; ESR1 protein alternative form inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA]; ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of NRF1 mRNA]; ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PDCD4 mRNA]; ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PDCD4 protein]; ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PTEN mRNA]; ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PTEN protein]; ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; ESR1 protein alternative form promotes the reaction [allyl sulfide inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; ESR1 protein alternative form promotes the reaction [allyl sulfide inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [allyl sulfide inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; ESR1 protein alternative form promotes the reaction [Estradiol results in decreased expression of CDH1 protein]; ESR1 protein alternative form promotes the reaction [Estradiol results in decreased expression of KRT18 protein]; ESR1 protein alternative form promotes the reaction [Estradiol results in increased expression of SNAI1 protein]; ESR1 protein alternative form promotes the reaction [Estradiol results in increased expression of SNAI2 protein]; ESR1 protein alternative form promotes the reaction [Estradiol results in increased expression of VIM protein]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; ESR1 protein inhibits the reaction [Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of PRSS23 mRNA]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; ESR1 protein promotes the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; ESR1 protein promotes the reaction [Estradiol inhibits the reaction [Potassium results in increased secretion of gamma-Aminobutyric Acid]]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of AGER protein]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CCN2 protein]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CYP2A6 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of DMBT1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FOS protein]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 protein]; ESR1 protein promotes the reaction [Estradiol results in increased expression of GLS protein]; ESR1 protein promotes the reaction [Estradiol results in increased expression of SERPINA6 protein]; ESR1 protein promotes the reaction [Estradiol results in increased expression of SERPINB9 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of SHBG protein]; ESR1 protein promotes the reaction [Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein]; ESR1 protein promotes the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; ESR1 protein promotes the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; ESR2 affects the reaction [Estradiol affects the expression of ESR1 mRNA]; Estradiol affects the reaction [daidzein metabolite affects the activity of ESR1 protein]; Estradiol affects the reaction [Equol affects the activity of ESR1 protein]; Estradiol affects the reaction [ESR1 protein binds to HELZ2 protein]; Estradiol affects the reaction [ESR1 protein binds to HR protein]; Estradiol affects the reaction [ESR1 protein binds to ITGB3BP protein]; Estradiol affects the reaction [ESR1 protein binds to NCOR1 protein]; Estradiol affects the reaction [ESR1 protein binds to NELFB protein]; Estradiol affects the reaction [ESR1 protein binds to NR0B2 protein]; Estradiol affects the reaction [ESR1 protein binds to PELP1 protein]; Estradiol affects the reaction [ESR1 protein binds to PROX1 protein]; Estradiol affects the reaction [ESR1 protein binds to TRERF1 protein]; Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein]; Estradiol affects the reaction [O-desmethylangolensin affects the activity of ESR1 protein]; Estradiol affects the reaction [Quercetin results in increased activity of ESR1 protein]; Estradiol affects the reaction [tetrahydrodaidzein affects the activity of ESR1 protein]; Estradiol analog promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estradiol analog promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]; Estradiol binds to and affects the folding of and results in increased activity of ESR1 protein; Estradiol binds to and affects the folding of ESR1 protein; Estradiol binds to and results in increased activity of ESR1 protein; Estradiol binds to and results in increased expression of ESR1 protein; Estradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estradiol inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to ESR1 protein]; Estradiol inhibits the reaction [[ESR1 protein binds to NCOR1 protein] which binds to TFF1 promoter]; Estradiol inhibits the reaction [Coumestrol binds to ESR1 protein]; Estradiol inhibits the reaction [ESR1 protein binds to CHD9 protein]; Estradiol inhibits the reaction [ESR1 protein binds to CNOT1 protein]; Estradiol inhibits the reaction [ESR1 protein binds to DHX30 protein]; Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]; Estradiol inhibits the reaction [ESR1 protein binds to GSN protein]; Estradiol inhibits the reaction [ESR1 protein binds to MEN1 protein]; Estradiol inhibits the reaction [ESR1 protein binds to MGMT protein]; Estradiol inhibits the reaction [ESR1 protein binds to MTA1 protein]; Estradiol inhibits the reaction [ESR1 protein binds to PAK6 protein]; Estradiol inhibits the reaction [ESR1 protein binds to PHB2 protein]; Estradiol inhibits the reaction [ESR1 protein binds to PRAME protein]; Estradiol inhibits the reaction [ESR1 protein binds to STUB1 protein]; Estradiol inhibits the reaction [ESR1 protein binds to TGFB1I1 protein]; Estradiol inhibits the reaction [ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; Estradiol inhibits the reaction [ESR1 protein promotes the reaction [BTRC protein binds to CTNNB1 protein]]; Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [bisphenol A results in decreased expression of ESR1 protein]]; Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter]]; Estradiol promotes the reaction [[ESR1 protein binds to AGR2 promoter] which results in increased expression of AGR2 mRNA]; Estradiol promotes the reaction [[ESR1 protein binds to AHR protein binds to NRIP1 protein] which binds to TFF1 promoter]; Estradiol promotes the reaction [[ESR1 protein binds to AHR protein binds to NRIP1 protein] which binds to TSKU promoter]; Estradiol promotes the reaction [[ESR1 protein binds to CTSD promoter] which results in increased expression of CTSD mRNA]; Estradiol promotes the reaction [[ESR1 protein binds to CYP2B6 promoter] which results in increased expression of CYP2B6 mRNA]; Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]; Estradiol promotes the reaction [[ESR1 protein binds to HSPB1 promoter] which results in increased expression of HSPB1 mRNA]; Estradiol promotes the reaction [[ESR1 protein binds to NCOA3 protein] which binds to TFF1 promoter]; Estradiol promotes the reaction [ACYP1 protein binds to ESR1 protein]; Estradiol promotes the reaction [ARF6 protein binds to ESR1 protein]; Estradiol promotes the reaction [Arsenic Trioxide results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [Arsenic Trioxide results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [ATP4A protein binds to ESR1 protein]; Estradiol promotes the reaction [C2CD3 protein binds to ESR1 protein]; Estradiol promotes the reaction [CATSPERE protein binds to ESR1 protein]; Estradiol promotes the reaction [CBX3 protein binds to ESR1 protein]; Estradiol promotes the reaction [CCDC158 protein binds to ESR1 protein]; Estradiol promotes the reaction [CCDC47 protein binds to ESR1 protein]; Estradiol promotes the reaction [CD58 protein binds to ESR1 protein]; Estradiol promotes the reaction [CDC14A protein binds to ESR1 protein]; Estradiol promotes the reaction [cobaltous chloride results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [cobaltous chloride results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [COG3 protein binds to ESR1 protein]; Estradiol promotes the reaction [CREBBP protein binds to ESR1 promoter]; Estradiol promotes the reaction [CTNNB1 protein binds to ESR1 protein]; Estradiol promotes the reaction [cupric chloride results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [cupric chloride results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [CYC1 protein binds to ESR1 protein]; Estradiol promotes the reaction [Cycloheximide results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [DNAJA3 protein binds to ESR1 protein]; Estradiol promotes the reaction [DNAJB11 protein binds to ESR1 protein]; Estradiol promotes the reaction [DYSF protein binds to ESR1 protein]; Estradiol promotes the reaction [EFHD2 protein binds to ESR1 protein]; Estradiol promotes the reaction [EFR3A protein binds to ESR1 protein]; Estradiol promotes the reaction [EIF2S1 protein binds to ESR1 protein]; Estradiol promotes the reaction [ENAH protein binds to ESR1 protein]; Estradiol promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Estradiol promotes the reaction [ESR1 protein binds to ADORA1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to AGR2 promoter]; Estradiol promotes the reaction [ESR1 protein binds to AGT promoter]; Estradiol promotes the reaction [ESR1 protein binds to AHR protein binds to NRIP1 protein]; Estradiol promotes the reaction [ESR1 protein binds to AICDA promoter]; Estradiol promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Estradiol promotes the reaction [ESR1 protein binds to AR protein]; Estradiol promotes the reaction [ESR1 protein binds to BLOC1S1 protein]; Estradiol promotes the reaction [ESR1 protein binds to BRCA1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to BRD8 protein]; Estradiol promotes the reaction [ESR1 protein binds to CCN5 promoter]; Estradiol promotes the reaction [ESR1 protein binds to CDKN1A promoter]; Estradiol promotes the reaction [ESR1 protein binds to CEBPB protein]; Estradiol promotes the reaction [ESR1 protein binds to CREBBP protein binds to BRCA1 protein]; Estradiol promotes the reaction [ESR1 protein binds to CREBBP protein]; Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]; Estradiol promotes the reaction [ESR1 protein binds to CYP1B1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to CYP2A6 promoter]; Estradiol promotes the reaction [ESR1 protein binds to DEK promoter]; Estradiol promotes the reaction [ESR1 protein binds to EP300 protein]; Estradiol promotes the reaction [ESR1 protein binds to ESR1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]; Estradiol promotes the reaction [ESR1 protein binds to ESR2 protein]; Estradiol promotes the reaction [ESR1 protein binds to EZH2 promoter]; Estradiol promotes the reaction [ESR1 protein binds to FOXM1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to GNAQ protein]; Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; Estradiol promotes the reaction [ESR1 protein binds to GREB1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to H19 gene]; Estradiol promotes the reaction [ESR1 protein binds to HELZ2 protein]; Estradiol promotes the reaction [ESR1 protein binds to HOXA10 gene]; Estradiol promotes the reaction [ESR1 protein binds to HOXA10 promoter]; Estradiol promotes the reaction [ESR1 protein binds to HOXB9 promoter]; Estradiol promotes the reaction [ESR1 protein binds to HOXC6 promoter]; Estradiol promotes the reaction [ESR1 protein binds to HSF2 protein]; Estradiol promotes the reaction [ESR1 protein binds to HSPB1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to HSPB8 promoter]; Estradiol promotes the reaction [ESR1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to IGF1R protein]; Estradiol promotes the reaction [ESR1 protein binds to ILK protein]; Estradiol promotes the reaction [ESR1 protein binds to JMJD1C protein]; Estradiol promotes the reaction [ESR1 protein binds to JUN protein]; Estradiol promotes the reaction [ESR1 protein binds to JUND promoter]; Estradiol promotes the reaction [ESR1 protein binds to KAT5 protein]; Estradiol promotes the reaction [ESR1 protein binds to KLRC1 gene]; Estradiol promotes the reaction [ESR1 protein binds to KLRC3 gene]; Estradiol promotes the reaction [ESR1 protein binds to KMT2B protein]; Estradiol promotes the reaction [ESR1 protein binds to KMT2D protein]; Estradiol promotes the reaction [ESR1 protein binds to LCN2 promoter]; Estradiol promotes the reaction [ESR1 protein binds to LCOR protein]; Estradiol promotes the reaction [ESR1 protein binds to LLGL2 gene]; Estradiol promotes the reaction [ESR1 protein binds to MAP4K3 promoter]; Estradiol promotes the reaction [ESR1 protein binds to MED1 protein]; Estradiol promotes the reaction [ESR1 protein binds to MMP1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]; Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]; Estradiol promotes the reaction [ESR1 protein binds to NCOA2 protein]; Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]; Estradiol promotes the reaction [ESR1 protein binds to NCOA6 protein]; Estradiol promotes the reaction [ESR1 protein binds to NELFB protein]; Estradiol promotes the reaction [ESR1 protein binds to NFKBIB protein]; Estradiol promotes the reaction [ESR1 protein binds to NKD1 gene]; Estradiol promotes the reaction [ESR1 protein binds to NR0B1 protein]; Estradiol promotes the reaction [ESR1 protein binds to NR0B2 protein]; Estradiol promotes the reaction [ESR1 protein binds to NRBF2 protein]; Estradiol promotes the reaction [ESR1 protein binds to NRIP1 protein]; Estradiol promotes the reaction [ESR1 protein binds to NSD1 protein]; Estradiol promotes the reaction [ESR1 protein binds to PAK6 protein]; Estradiol promotes the reaction [ESR1 protein binds to PELP1 protein]; Estradiol promotes the reaction [ESR1 protein binds to PNRC1 protein]; Estradiol promotes the reaction [ESR1 protein binds to PNRC2 protein]; Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to PPARGC1A protein]; Estradiol promotes the reaction [ESR1 protein binds to PPARGC1B protein]; Estradiol promotes the reaction [ESR1 protein binds to PPRC1 protein]; Estradiol promotes the reaction [ESR1 protein binds to PRAME protein]; Estradiol promotes the reaction [ESR1 protein binds to PROX1 protein]; Estradiol promotes the reaction [ESR1 protein binds to PTGS2 promoter]; Estradiol promotes the reaction [ESR1 protein binds to RBL2 protein]; Estradiol promotes the reaction [ESR1 protein binds to RORA promoter]; Estradiol promotes the reaction [ESR1 protein binds to SCAND1 protein]; Estradiol promotes the reaction [ESR1 protein binds to SERPINB9 protein]; Estradiol promotes the reaction [ESR1 protein binds to SHC1 protein]; Estradiol promotes the reaction [ESR1 protein binds to SLC30A9 protein]; Estradiol promotes the reaction [ESR1 protein binds to SOCS3 promoter]; Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]; Estradiol promotes the reaction [ESR1 protein binds to SPATA13 gene]; Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to TFF1 protein]; Estradiol promotes the reaction [ESR1 protein binds to TFF2 promoter]; Estradiol promotes the reaction [ESR1 protein binds to TMEM121B gene]; Estradiol promotes the reaction [ESR1 protein binds to TRIM24 protein mutant form]; Estradiol promotes the reaction [ESR1 protein binds to TRIM24 protein]; Estradiol promotes the reaction [ESR1 protein binds to TRIP4 protein]; Estradiol promotes the reaction [ESR1 protein binds to TRRAP protein mutant form]; Estradiol promotes the reaction [ESR1 protein binds to TRRAP protein]; Estradiol promotes the reaction [ESR1 protein binds to TSC22D3 promoter]; Estradiol promotes the reaction [ESR1 protein binds to TSKU promoter]; Estradiol promotes the reaction [ESR1 protein binds to TTF1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to TXNRD1 protein]; Estradiol promotes the reaction [ESR1 protein binds to UBE3A protein]; Estradiol promotes the reaction [ESR1 protein binds to WIPI1 protein]; Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]; Estradiol promotes the reaction [ESR1 protein binds to XBP1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to ZNHIT3 protein]; Estradiol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estradiol promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]; Estradiol promotes the reaction [ESR1 protein results in increased expression of TNF mRNA]; Estradiol promotes the reaction [ESR1 results in increased expression of CYP19A1 mRNA alternative form]; Estradiol promotes the reaction [ESR1 results in increased expression of CYP19A1 protein]; Estradiol promotes the reaction [FHL2 protein binds to ESR1 protein]; Estradiol promotes the reaction [FLNC protein binds to ESR1 protein]; Estradiol promotes the reaction [GIPC1 protein binds to ESR1 protein]; Estradiol promotes the reaction [GLUD1 protein binds to ESR1 protein]; Estradiol promotes the reaction [GNA12 protein binds to ESR1 protein]; Estradiol promotes the reaction [GNAQ protein binds to ESR1 protein]; Estradiol promotes the reaction [GNB3 protein binds to ESR1 protein]; Estradiol promotes the reaction [GPC4 protein binds to ESR1 protein]; Estradiol promotes the reaction [H1-3 protein binds to ESR1 protein]; Estradiol promotes the reaction [HSD17B10 protein binds to ESR1 protein]; Estradiol promotes the reaction [HSPA7 protein binds to ESR1 protein]; Estradiol promotes the reaction [IDH3A protein binds to ESR1 protein]; Estradiol promotes the reaction [INF2 protein binds to ESR1 protein]; Estradiol promotes the reaction [JPT2 protein binds to ESR1 protein]; Estradiol promotes the reaction [KARS1 protein binds to ESR1 protein]; Estradiol promotes the reaction [KHDRBS2 protein binds to ESR1 protein]; Estradiol promotes the reaction [KRT28 protein binds to ESR1 protein]; Estradiol promotes the reaction [KRT33B protein binds to ESR1 protein]; Estradiol promotes the reaction [L1CAM-AS1 protein binds to ESR1 protein]; Estradiol promotes the reaction [lead chloride results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [lead chloride results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [LMNB2 protein binds to ESR1 protein]; Estradiol promotes the reaction [LRRFIP1 protein binds to ESR1 protein]; Estradiol promotes the reaction [MAGOH protein binds to ESR1 protein]; Estradiol promotes the reaction [MED25 protein binds to ESR1 protein]; Estradiol promotes the reaction [N4BP3 protein binds to ESR1 protein]; Estradiol promotes the reaction [NCOA1 protein binds to ESR1 protein]; Estradiol promotes the reaction [NCOA2 protein binds to ESR1 protein]; Estradiol promotes the reaction [NCOA3 protein binds to ESR1 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to ESR1 protein]; Estradiol promotes the reaction [NDUFS3 protein binds to ESR1 protein]; Estradiol promotes the reaction [NEMF protein binds to ESR1 protein]; Estradiol promotes the reaction [NTPCR protein binds to ESR1 protein]; Estradiol promotes the reaction [P2RX4 protein binds to ESR1 protein]; Estradiol promotes the reaction [PABPN1 protein binds to ESR1 protein]; Estradiol promotes the reaction [PAPSS1 protein binds to ESR1 protein]; Estradiol promotes the reaction [PDK3 protein binds to ESR1 protein]; Estradiol promotes the reaction [PGAM4 protein binds to ESR1 protein]; Estradiol promotes the reaction [PIAS1 protein binds to ESR1 protein]; Estradiol promotes the reaction [PLEKHG3 protein binds to ESR1 protein]; Estradiol promotes the reaction [PSME3 protein binds to ESR1 protein]; Estradiol promotes the reaction [PUF60 protein binds to ESR1 protein]; Estradiol promotes the reaction [RABEP1 protein binds to ESR1 protein]; Estradiol promotes the reaction [RBBP7 protein binds to ESR1 protein]; Estradiol promotes the reaction [RFFL protein binds to ESR1 protein]; Estradiol promotes the reaction [SEMG1 protein binds to ESR1 protein]; Estradiol promotes the reaction [SF1 protein binds to ESR1 protein]; Estradiol promotes the reaction [SHC1 protein binds to ESR1 protein]; Estradiol promotes the reaction [SIN3A protein binds to ESR1 promoter]; Estradiol promotes the reaction [SLC25A1 protein binds to ESR1 protein]; Estradiol promotes the reaction [SMC4 protein binds to ESR1 protein]; Estradiol promotes the reaction [SMPDL3B protein binds to ESR1 protein]; Estradiol promotes the reaction [SMYD1 protein binds to ESR1 protein]; Estradiol promotes the reaction [SNRPF protein binds to ESR1 protein]; Estradiol promotes the reaction [SORBS1 protein binds to ESR1 protein]; Estradiol promotes the reaction [SPAG1 protein binds to ESR1 protein]; Estradiol promotes the reaction [SPTB protein binds to ESR1 protein]; Estradiol promotes the reaction [SRPRB protein binds to ESR1 protein]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; Estradiol promotes the reaction [THEM6 protein binds to ESR1 protein]; Estradiol promotes the reaction [THRAP3 protein binds to ESR1 protein]; Estradiol promotes the reaction [TMEM205 protein binds to ESR1 protein]; Estradiol promotes the reaction [TOMM70A protein binds to ESR1 protein]; Estradiol promotes the reaction [TRIM2 protein binds to ESR1 protein]; Estradiol promotes the reaction [TSFM protein binds to ESR1 protein]; Estradiol promotes the reaction [TUBB2A protein binds to ESR1 protein]; Estradiol promotes the reaction [UBE2I protein binds to ESR1 protein]
