Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDEthanol results in decreased expression of ESR1 mRNA; Ethanol results in decreased expression of ESR1 proteinPMID:23273579 PMID:23591044
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDEthanol results in increased expression of ESR1 mRNA; Ethanol results in increased expression of ESR1 proteinPMID:23591044 PMID:29769550
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDEthanol results in increased expression of ESR1 proteinPMID:15659783
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD[Ethanol co-treated with Melatonin] results in decreased expression of ESR1 protein; [Ethanol co-treated with Melatonin] results in increased expression of ESR1 proteinPMID:23591044
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDESR1 promotes the reaction [Ethanol results in increased expression of and results in increased activity of RUNX2 protein]PMID:32198086
Go Back to source page   Continue to Ontology report