GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects expression | EXP | | 6480464 | CTD | Oxygen deficiency affects the expression of ESR1 protein; Oxygen deficiency affects the expression of ESR1 protein alternative form | PMID:28859903 | Esr1 | decreases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in decreased expression of ESR1 mRNA | PMID:24846829 | Esr1 | multiple interactions | EXP | | 6480464 | CTD | [Raloxifene Hydrochloride co-treated with Oxygen deficiency] results in increased expression of ESR1 protein; bazedoxifene affects the reaction [Oxygen deficiency affects the expression of ESR1 protein alternative form]; bazedoxifene affects the reaction [Oxygen deficiency affects the expression of ESR1 protein]; Raloxifene Hydrochloride affects the reaction [Oxygen deficiency affects the expression of ESR1 protein alternative form]; Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA] | PMID:24846829 PMID:28859903 | Esr1 | affects expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Oxygen deficiency affects the expression of ESR1 mRNA; Oxygen deficiency affects the expression of ESR1 protein | PMID:24333797 | Esr1 | decreases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Oxygen deficiency results in decreased expression of ESR1 mRNA; Oxygen deficiency results in decreased expression of ESR1 protein | PMID:24333797 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in decreased expression of ESR1 mRNA; Oxygen deficiency results in decreased expression of ESR1 protein | PMID:19578757 PMID:30851587 | Esr1 | increases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Oxygen deficiency results in increased expression of ESR1 mRNA; Oxygen deficiency results in increased expression of ESR1 protein | PMID:15927375 PMID:18457817 | Esr1 | multiple interactions | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of ESR1 mRNA; Estradiol affects the reaction [Oxygen deficiency affects the expression of ESR1 mRNA]; Estradiol affects the reaction [Oxygen deficiency affects the expression of ESR1 protein]; Estradiol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA]; Genistein affects the reaction [Oxygen deficiency affects the expression of ESR1 mRNA]; Genistein affects the reaction [Oxygen deficiency affects the expression of ESR1 protein]; Genistein inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA]; parthenocissin A analog affects the reaction [Oxygen deficiency affects the expression of ESR1 mRNA]; parthenocissin A analog affects the reaction [Oxygen deficiency affects the expression of ESR1 protein]; parthenocissin A analog affects the reaction [Oxygen deficiency results in decreased expression of ESR1 protein]; parthenocissin A analog inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA]; Resveratrol affects the reaction [Oxygen deficiency affects the expression of ESR1 mRNA]; Resveratrol affects the reaction [Oxygen deficiency affects the expression of ESR1 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA]; tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of ESR1 mRNA] | PMID:24333797 PMID:37606869 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [Oxygen deficiency co-treated with Diethylhexyl Phthalate] results in decreased expression of ESR1 protein; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased activity of ESR1 protein; Oxygen deficiency promotes the reaction [bisphenol A results in decreased expression of ESR1 mRNA]; Oxygen deficiency promotes the reaction [bisphenol A results in decreased expression of ESR1 protein]; Oxygen deficiency promotes the reaction [butylbenzyl phthalate results in decreased expression of ESR1 mRNA]; Oxygen deficiency promotes the reaction [butylbenzyl phthalate results in decreased expression of ESR1 protein]; Oxygen deficiency promotes the reaction [Diethylhexyl Phthalate results in decreased expression of ESR1 mRNA]; Oxygen deficiency promotes the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Oxygen deficiency promotes the reaction [Estradiol results in decreased expression of ESR1 protein] | PMID:19578757 PMID:30851587 | | ||||||||||||||||||||||
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