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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingEXP 6480464CTDZearalenone binds to ESR1 proteinPMID:11162928 PMID:19913605
Esr1decreases expressionEXP 6480464CTDZearalenone results in decreased expression of ESR1 mRNA; Zearalenone results in decreased expression of ESR1 proteinPMID:27862621 PMID:30270565 PMID:31419471
Esr1multiple interactionsEXP 6480464CTDZearalenone binds to and results in increased activity of ESR1 proteinPMID:20209442 PMID:22494775
Esr1affects bindingISOEsr1 (Rattus norvegicus)6480464CTDZearalenone binds to ESR1 proteinPMID:19913605
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDZearalenone analog binds to ESR1 protein; Zearalenone binds to ESR1 proteinPMID:11162928 PMID:12598185 PMID:15169976 PMID:19233257 PMID:19913605 PMID:28807876
Esr1affects expressionISOEsr1 (Rattus norvegicus)6480464CTDZearalenone affects the expression of ESR1 mRNA; Zearalenone affects the expression of ESR1 proteinPMID:22521637 PMID:29627501
Esr1affects response to substanceISOESR1 (Homo sapiens)6480464CTDESR1 protein affects the susceptibility to ZearalenonePMID:33419253
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDZearalenone results in decreased expression of ESR1 mRNAPMID:28965971
Esr1increases activityISOEsr1 (Rattus norvegicus)6480464CTDZearalenone results in increased activity of ESR1 proteinPMID:11750080
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDZearalenone metabolite results in increased activity of ESR1 protein; Zearalenone results in increased activity of ESR1 proteinPMID:11331656 PMID:25455890 PMID:28396216
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein; Fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]; Zearalenone analog promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone binds to and results in decreased activity of ESR1 protein; Zearalenone binds to and results in increased activity of ESR1 protein; Zearalenone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Zearalenone promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein]PMID:12650720 PMID:15084758 PMID:19233257 PMID:28807876 PMID:33049310 PMID:9751507
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