GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | EXP | | 6480464 | CTD | Zearalenone binds to ESR1 protein | PMID:11162928 PMID:19913605 | Esr1 | decreases expression | EXP | | 6480464 | CTD | Zearalenone results in decreased expression of ESR1 mRNA; Zearalenone results in decreased expression of ESR1 protein | PMID:27862621 PMID:30270565 PMID:31419471 | Esr1 | multiple interactions | EXP | | 6480464 | CTD | Zearalenone binds to and results in increased activity of ESR1 protein | PMID:20209442 PMID:22494775 | Esr1 | affects binding | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Zearalenone binds to ESR1 protein | PMID:19913605 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Zearalenone analog binds to ESR1 protein; Zearalenone binds to ESR1 protein | PMID:11162928 PMID:12598185 PMID:15169976 PMID:19233257 PMID:19913605 PMID:28807876 | Esr1 | affects expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Zearalenone affects the expression of ESR1 mRNA; Zearalenone affects the expression of ESR1 protein | PMID:22521637 PMID:29627501 | Esr1 | affects response to substance | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | ESR1 protein affects the susceptibility to Zearalenone | PMID:33419253 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Zearalenone results in decreased expression of ESR1 mRNA | PMID:28965971 | Esr1 | increases activity | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Zearalenone results in increased activity of ESR1 protein | PMID:11750080 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Zearalenone metabolite results in increased activity of ESR1 protein; Zearalenone results in increased activity of ESR1 protein | PMID:11331656 PMID:25455890 PMID:28396216 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein; Fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]; Zearalenone analog promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone binds to and results in decreased activity of ESR1 protein; Zearalenone binds to and results in increased activity of ESR1 protein; Zearalenone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Zearalenone promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein] | PMID:12650720 PMID:15084758 PMID:19233257 PMID:28807876 PMID:33049310 PMID:9751507 | |
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