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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510 Species: Mus musculus RGD Object: Gene Symbol: Egf Name: epidermal growth factor

Acc ID: CHEBI:8093 Term: phenylephrine Definition: A phenylethanolamine that has formula C9H13NO2. CasRN: 59-42-7 Chemical ID: MESH:D010656

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2542	6480464	CTD	ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein] [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein] [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]	PMID:16760267