• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473 Species: Mus musculus RGD Object: Gene Symbol: Nqo1 Name: NAD(P)H dehydrogenase, quinone 1

Acc ID: CHEBI:27889 Term: lead(0) Definition: An elemental lead that has formula Pb. CasRN: 7439-92-1 Chemical ID: MESH:D007854

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Cycloheximide inhibits the reaction [Lead results in increased expression of NQO1 mRNA] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of NQO1 mRNA]] Dactinomycin inhibits the reaction [Lead results in increased expression of NQO1 mRNA] Lead promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA] Lead promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein] NFE2L2 protein affects the reaction [Lead results in increased expression of NQO1 mRNA]	PMID:16243960
increases activity	EXP		6480464	CTD	Lead results in increased activity of NQO1 protein	PMID:16243960
increases expression	EXP		6480464	CTD	Lead results in increased expression of NQO1 mRNA	PMID:16243960
increases expression	EXP		6480464	CTD	Lead results in increased expression of NQO1 mRNA	PMID:18752316 PMID:16243960
increases expression	ISO	RGD:735868	6480464	CTD	Lead results in increased expression of NQO1 mRNA	PMID:22120038
increases expression	EXP		6480464	CTD	Lead results in increased expression of NQO1 protein	PMID:18752316
multiple interactions	EXP		6480464	CTD	anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Lead results in increased expression of NQO1 mRNA] anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Lead results in increased expression of NQO1 protein] Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of NQO1 mRNA] Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of NQO1 protein] prolinedithiocarbamate promotes the reaction [Lead results in increased expression of NQO1 mRNA] SB 203580 promotes the reaction [Lead results in increased expression of NQO1 mRNA] Tetradecanoylphorbol Acetate inhibits the reaction [Lead results in increased expression of NQO1 mRNA] Tetradecanoylphorbol Acetate inhibits the reaction [Lead results in increased expression of NQO1 protein] U 0126 promotes the reaction [Lead results in increased expression of NQO1 mRNA]	PMID:18752316
increases expression	EXP		6480464	CTD	Lead results in increased expression of NQO1 mRNA	PMID:16243960 PMID:18752316