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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473 Species: Mus musculus RGD Object: Gene Symbol: Nqo1 Name: NAD(P)H dehydrogenase, quinone 1

Acc ID: CHEBI:27641 Term: cycloheximide Definition: A piperidine antibiotic that has formula C15H23NO4. CasRN: 66-81-9 Chemical ID: MESH:D003513

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of NQO1 mRNA]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of NQO1 mRNA]]	PMID:16243960
multiple interactions	EXP		6480464	CTD	Cycloheximide inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]	PMID:14510636
multiple interactions	EXP		6480464	CTD	Cycloheximide inhibits the reaction [arsenite results in increased expression of NQO1 mRNA] Cycloheximide inhibits the reaction [Cadmium results in increased expression of NQO1 mRNA] Cycloheximide promotes the reaction [Chromium results in increased expression of NQO1 mRNA]	PMID:18474416
multiple interactions	EXP		6480464	CTD	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]	PMID:16243960 PMID:18474416 PMID:14510636
decreases expression	EXP		6480464	CTD	Cycloheximide results in decreased expression of NQO1 mRNA	PMID:16243960 PMID:18474416
multiple interactions	EXP		6480464	CTD	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]	PMID:18474416 PMID:14510636 PMID:16243960
multiple interactions	EXP		6480464	CTD	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]	PMID:16243960 PMID:14510636 PMID:18474416
decreases expression	EXP		6480464	CTD	Cycloheximide results in decreased expression of NQO1 mRNA	PMID:18474416 PMID:16243960
multiple interactions	EXP		6480464	CTD	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]	PMID:18474416 PMID:16243960 PMID:14510636
multiple interactions	EXP		6480464	CTD	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]	PMID:14510636 PMID:16243960 PMID:18474416