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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10460 Species: Mus musculus RGD Object: Gene Symbol: Dbh Name: dopamine beta hydroxylase

Acc ID: CHEBI:41879 Term: dexamethasone Definition: A fluorinated steroid that has formula C22H29FO5. CasRN: 50-02-2 Chemical ID: MESH:D003907

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2489	6480464	CTD	Dexamethasone inhibits the reaction [Atrazine results in decreased expression of DBH protein] Dexamethasone inhibits the reaction [Simazine results in decreased expression of DBH protein]	PMID:14550852
increases expression	ISO	RGD:2489	6480464	CTD	Dexamethasone results in increased expression of DBH protein	PMID:14550852
multiple interactions	ISO	RGD:2489	6480464	CTD	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of DBH mRNA]	PMID:20032058
decreases expression	ISO	RGD:2489	6480464	CTD	Dexamethasone results in decreased expression of DBH mRNA	PMID:20032058