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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10451 Species: Mus musculus RGD Object: Gene Symbol: Cyp2e1 Name: cytochrome P450, family 2, subfamily e, polypeptide 1

Acc ID: CHEBI:52497 Term: maneb Definition: A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. CasRN: 12427-38-2 Chemical ID: MESH:D008344

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:2475	6480464	CTD	Maneb results in decreased activity of CYP2E1 protein	PMID:11043497
multiple interactions	EXP		6480464	CTD	[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA	PMID:16510128
increases activity	ISO	RGD:2475	6480464	CTD	Maneb results in increased activity of CYP2E1 protein	PMID:20888808
increases expression	ISO	RGD:2475	6480464	CTD	Maneb results in increased expression of CYP2E1 mRNA Maneb results in increased expression of CYP2E1 protein	PMID:20888808
multiple interactions	EXP		6480464	CTD	Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein] Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein] [Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA] Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	PMID:20964710
multiple interactions	ISO	RGD:2475	6480464	CTD	Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein] Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA] Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA] [Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein] Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein] Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA] Silymarin inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein] Silymarin inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]	PMID:23159886
increases expression	ISO	RGD:2475	6480464	CTD	Maneb results in increased expression of CYP2E1 mRNA	PMID:20888808 PMID:23159886