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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438 Species: Mus musculus RGD Object: Gene Symbol: Cyp1a2 Name: cytochrome P450, family 1, subfamily a, polypeptide 2

Acc ID: CHEBI:28177 Term: theophylline Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 3. CasRN: 58-55-9 Chemical ID: MESH:D013806

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein results in increased metabolism of Theophylline	PMID:9701106 PMID:11483122
affects metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:15970798 PMID:15948934 PMID:15692829
multiple interactions	ISO	RGD:735711	6480464	CTD	[Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline]	PMID:11408986
decreases activity	ISO	RGD:735711	6480464	CTD	Theophylline results in decreased activity of CYP1A2 protein	PMID:11465391
multiple interactions	ISO	RGD:735711	6480464	CTD	zafirlukast inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline]	PMID:9701106
affects metabolic processing	ISO	RGD:2459	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:15720787 PMID:15985363
affects metabolic processing	EXP		6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:15970798
multiple interactions	ISO	RGD:2459	6480464	CTD	rutecarpine promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]	PMID:15720787
affects metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:15948934 PMID:15970798 PMID:15692829
increases metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein results in increased metabolism of Theophylline	PMID:11483122 PMID:9701106
multiple interactions	ISO	RGD:2459	6480464	CTD	andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline] Plant Extracts affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]	PMID:20096675
increases metabolic processing	ISO	RGD:2459	6480464	CTD	CYP1A2 protein results in increased metabolism of Theophylline	PMID:20096675
affects metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 gene SNP affects the metabolism of Theophylline	PMID:20797314
affects hydroxylation	ISO	RGD:735711	6480464	CTD	CYP1A2 promoter SNP affects the hydroxylation of Theophylline	PMID:16841220
affects metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:16841220 PMID:15692829 PMID:15970798 PMID:15948934
affects response to substance	ISO	RGD:735711	6480464	CTD	CYP1A2 gene SNP affects the susceptibility to Theophylline	PMID:12732846
affects metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:15692829 PMID:12732846 PMID:9029748 PMID:15970798 PMID:16841220 PMID:15948934
increases chemical synthesis	ISO	RGD:735711	6480464	CTD	CYP1A2 protein results in increased chemical synthesis of Theophylline	PMID:1302044
multiple interactions	ISO	RGD:735711	6480464	CTD	Griseofulvin promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline] Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]	PMID:9029748
affects metabolic processing	ISO	RGD:2459	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:15985363 PMID:15720787
affects metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:16841220 PMID:15948934 PMID:15970798 PMID:9029748 PMID:12732846 PMID:15692829
affects metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:15692829 PMID:12732846 PMID:15948934 PMID:15970798 PMID:9029748 PMID:16841220
affects metabolic processing	ISO	RGD:735711	6480464	CTD	CYP1A2 protein affects the metabolism of Theophylline	PMID:12732846 PMID:15692829 PMID:15948934 PMID:15970798 PMID:16841220 PMID:9029748