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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10326 Species: Mus musculus RGD Object: Gene Symbol: Cebpb Name: CCAAT/enhancer binding protein (C/EBP), beta

Acc ID: CHEBI:3374 Term: capsaicin Definition: A capsaicinoid that has formula C18H27NO3. CasRN: 404-86-4 Chemical ID: MESH:D002211

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA] [Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]	PMID:21250977
increases activity	EXP		6480464	CTD	Capsaicin results in increased activity of CEBPB protein	PMID:21250977
multiple interactions	ISO	RGD:736208	6480464	CTD	Capsaicin promotes the reaction [CEBPB protein binds to ATF3 protein binds to GSK3B protein] [CEBPB protein binds to GDF15 promoter] promotes the reaction [Capsaicin results in increased expression of GDF15 mRNA] CEBPB mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA] CEBPB protein promotes the reaction [Capsaicin results in increased expression of GDF15 mRNA]	PMID:20110283