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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10270
Species: Mus musculus
RGD Object: Gene
Symbol: Cacnb3
Name: calcium channel, voltage-dependent, beta 3 subunit
Acc ID: CHEBI:42797
Term: gabapentin
Definition: A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Chemical ID: MESH:C040029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacnb3multiple interactionsISOCacnb3 (Rattus norvegicus)6480464CTDCACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]; gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]; gabapentin affects the reaction [[CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium]PMID:19796812
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