RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10109
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Adrb2
Name:	adrenergic receptor, beta 2

Acc ID:	CHEBI:8499
Term:	propranolol
Definition:	A propanolamine that has formula C16H21NO2.
CasRN:	525-66-6
Chemical ID:	MESH:D011433

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:733595	6480464	CTD	Propranolol results in decreased expression of ADRB2 mRNA	PMID:15603589
affects binding	ISO	RGD:2060	6480464	CTD	Propranolol binds to ADRB2 protein	PMID:9593075 PMID:11483288
multiple interactions	ISO	RGD:2060	6480464	CTD	Propranolol binds to and results in decreased activity of ADRB2 protein	PMID:11425575 PMID:2897299
multiple interactions	ISO	RGD:733595	6480464	CTD	Propranolol binds to and results in decreased activity of ADRB2 protein	PMID:10952688 PMID:6141285
affects binding	ISO	RGD:733595	6480464	CTD	Propranolol binds to ADRB2 protein	PMID:2169833
multiple interactions	ISO	RGD:733595	6480464	CTD	Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein] Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP] Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein] Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein] Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP] Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein] Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	PMID:12920204
multiple interactions	ISO	RGD:733595	6480464	CTD	Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	PMID:10952688 PMID:12920204
multiple interactions	ISO	RGD:733595	6480464	CTD	Propranolol binds to and results in decreased activity of ADRB2 protein	PMID:6141285 PMID:10952688
affects binding	ISO	RGD:2060	6480464	CTD	Propranolol binds to ADRB2 protein	PMID:11483288 PMID:9593075
multiple interactions	ISO	RGD:733595	6480464	CTD	Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	PMID:12920204 PMID:10952688
multiple interactions	ISO	RGD:733595	6480464	CTD	[Propranolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP [Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]] Propranolol inhibits the reaction [carvedilol results in increased phosphorylation of ADRB2 protein] [Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein	PMID:17925438
affects binding	ISO	RGD:733595	6480464	CTD	Propranolol binds to ADRB2 protein	PMID:10372227 PMID:2169833
multiple interactions	ISO	RGD:733595	6480464	CTD	[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP Propranolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]	PMID:14730417
multiple interactions	ISO	RGD:733595	6480464	CTD	Propranolol binds to and results in decreased activity of ADRB2 protein	PMID:10952688 PMID:14730417 PMID:6141285
multiple interactions	ISO	RGD:733595	6480464	CTD	[Propranolol co-treated with ADRB2 protein] results in increased expression of GNAS protein [Propranolol co-treated with ADRB2 protein] results in increased expression of ADRBK1 protein	PMID:10455254
affects binding	ISO	RGD:2060	6480464	CTD	Propranolol binds to ADRB2 protein	PMID:11483288 PMID:9593075 PMID:2462161
multiple interactions	ISO	RGD:2060	6480464	CTD	Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein] Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]	PMID:2462161
increases expression	ISO	RGD:2060	6480464	CTD	Propranolol results in increased expression of ADRB2 mRNA	PMID:20668454
affects binding	ISO	RGD:733595	6480464	CTD	Propranolol binds to ADRB2 protein	PMID:2169833 PMID:10372227
multiple interactions	ISO	RGD:733595	6480464	CTD	Propranolol binds to and results in decreased activity of ADRB2 protein	PMID:10952688 PMID:6141285 PMID:14730417
affects binding	ISO	RGD:2060	6480464	CTD	Propranolol binds to ADRB2 protein	PMID:11483288 PMID:2462161 PMID:9593075
multiple interactions	ISO	RGD:733595	6480464	CTD	Propranolol binds to and results in decreased activity of ADRB2 protein	PMID:6141285 PMID:10952688 PMID:14730417
multiple interactions	ISO	RGD:2060	6480464	CTD	Propranolol binds to and results in decreased activity of ADRB2 protein	PMID:2897299 PMID:11425575

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