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GENE - TERM ANNOTATION REPORT

9 Annotations Found.

An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Barroso I, etal., Diabetes. 2008 Nov;57(11):3161-5. Epub 2008 Aug 26.
  • The annotation has been inferred from sequence orthology with HNF4A (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 2 additional annotations were made from Barroso I, etal., Diabetes. 2008 Nov;57(11):3161-5. Epub 2008 Aug 26.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a
  • Qualifier: susceptibility
  • Curation Notes: DNA:SNPs:promoter:(human)


    • An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Menjivar M, etal., Clin Genet. 2008 Feb;73(2):185-7. Epub 2007 Nov 19.
  • The annotation has been inferred from sequence orthology with HNF4A (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 2 additional annotations were made from Menjivar M, etal., Clin Genet. 2008 Feb;73(2):185-7. Epub 2007 Nov 19.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a
  • Qualifier: susceptibility
  • Curation Notes: DNA:missense mutation:exon:p.T130I


    • An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from expression pattern (IEP)
    		•  
  • The annotation was made from Borlak J and Niehof M, PLoS One. 2009;4(3):e4662. doi: 10.1371/journal.pone.0004662. Epub 2009 Mar 2.
  • 2 additional annotations were made from Borlak J and Niehof M, PLoS One. 2009;4(3):e4662. doi: 10.1371/journal.pone.0004662. Epub 2009 Mar 2.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a
  • Curation Notes: mRNA:decreased expression:liver,pancreas


    • An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Xie X, etal., Mol Endocrinol. 2009 Apr;23(4):434-43. doi: 10.1210/me.2007-0531. Epub 2009 Jan 29.
  • The annotation has been inferred from sequence orthology with Hnf4a (Mus musculus) [(IEP) inferred from expression pattern]
  • 5 additional annotations were made from Xie X, etal., Mol Endocrinol. 2009 Apr;23(4):434-43. doi: 10.1210/me.2007-0531. Epub 2009 Jan 29.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a
  • Curation Notes: protein:decreased expression:liver:


    • An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Yamagata K, etal., Nature. 1996 Dec 5;384(6608):458-60.
  • The annotation has been inferred from sequence orthology with HNF4A (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 2 additional annotations were made from Yamagata K, etal., Nature. 1996 Dec 5;384(6608):458-60.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a
  • Curation Notes: type I maturity-onset diabetes of the young, OMIM:125850


    • An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Holmkvist J, etal., Diabetes. 2008 Jun;57(6):1738-44. Epub 2008 Mar 10.
  • The annotation has been inferred from sequence orthology with HNF4A (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 6 additional annotations were made from Holmkvist J, etal., Diabetes. 2008 Jun;57(6):1738-44. Epub 2008 Mar 10.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a
  • Qualifier: susceptibility
  • Curation Notes: DNA:SNP::rs4810424 and rs3212198 nominally associated with future risk of developing T2DM (p=0.04) (human)


    • An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from OMIM Disease Annotation Pipeline
  • The annotation has been inferred from sequence orthology with HNF4A (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a


    • An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for CTD gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with HNF4A (Homo sapiens) [(EXP) inferred from experiment]
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a
  • Curation Notes: CTD Direct Evidence: marker/mechanism
  • Original References(s): PMID:17317762 PMID:21874001 PMID:22158537


    • An association has been curated linking Hnf4a and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with HNF4A (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 57 papers in RGD have been used to annotate Hnf4a
  • Curation Notes: ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus
  • Original References(s): PMID:10227563 PMID:10447526 PMID:10983627 PMID:12669197 PMID:15281001 PMID:16883527 PMID:16946562 PMID:17563455 PMID:18268044 PMID:18414213 PMID:21105491 PMID:23227446 PMID:23247789 PMID:23268925 PMID:24033266 PMID:24097065 PMID:25041077 PMID:25741868 PMID:25905084 PMID:26059258 PMID:26467025 PMID:26981542 PMID:27080136 PMID:27420379 PMID:27884173 PMID:28492532 PMID:29355436 PMID:29792621 PMID:30191603 PMID:31264968 PMID:31595705 PMID:32583173 PMID:33846082 PMID:34373539 PMID:34805411 PMID:35052457 PMID:35118593 PMID:35256061 PMID:36257325 PMID:9449683


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